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Recent strategies for evoking immunogenic Pyroptosis in antitumor immunotherapy
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2024-01-09 , DOI: 10.1016/j.jconrel.2023.12.023
Zhangxin He 1 , Dexiang Feng 2 , Chaoji Zhang 3 , Zhiqian Chen 2 , He Wang 2 , Jianquan Hou 2 , Shengliang Li 4 , Xuedong Wei 5
Affiliation  

Pyroptosis is a specific type of programmed cell death (PCD) characterized by distinct morphological changes, including cell swelling, membrane blebbing, DNA fragmentation, and eventual cell lysis. Pyroptosis is closely associated with human-related diseases, such as inflammation and malignancies. Since the initial observation of pyroptosis in Shigella flexneri-infected macrophages more than 20 years ago, various pyroptosis-inducing agents, including ions, small molecules, and biological nanomaterials, have been developed for tumor treatment. Given that pyroptosis can activate the body's robust immune response against tumor and promote the formation of the body's long-term immune memory in tumor treatment, its status as a type of immunogenic cell death is self-evident. Therefore, pyroptosis should be used as a powerful anti-tumor strategy. However, there still is a lack of a comprehensive summary of the most recent advances in pyroptosis-based cancer therapy. Therefore, it is vital to fill this gap and inspire future drug design to better induce tumor cells to undergo pyroptosis to achieve advanced anti-tumor effects. In this review, we summarize in detail the most recent advances in triggering tumor cell immunogenic pyroptosis for adequate tumor clearance based on various treatment modalities, and highlight material design and therapeutic advantages. Besides, we also provide an outlook on the prospects of this emerging field in the next development.

中文翻译:


在抗肿瘤免疫治疗中诱发免疫原性 Pyroptis 的最新策略



细胞焦亡是一种特定类型的程序性细胞死亡 (PCD),其特征是不同的形态变化,包括细胞肿胀、膜起泡、DNA 片段化和最终的细胞裂解。细胞焦亡与人类相关疾病密切相关,例如炎症和恶性肿瘤。自 20 多年前在福氏志贺氏菌感染的巨噬细胞中首次观察到焦亡以来,已经开发了各种焦亡诱导剂,包括离子、小分子和生物纳米材料,用于治疗肿瘤。鉴于焦亡可以激活机体对肿瘤的强大免疫反应,促进机体在肿瘤治疗中长期免疫记忆的形成,其作为一种免疫原性细胞死亡的地位是不言而喻的。因此,应将细胞焦亡作为一种强大的抗肿瘤策略。然而,仍然缺乏对基于 pyroptisis 的癌症治疗最新进展的全面总结。因此,填补这一空白并激发未来的药物设计以更好地诱导肿瘤细胞进行焦亡以达到先进的抗肿瘤效果至关重要。在这篇综述中,我们详细总结了基于各种治疗方式触发肿瘤细胞免疫原性焦亡以充分清除肿瘤的最新进展,并强调了材料设计和治疗优势。此外,我们还对这一新兴领域在未来发展中的前景进行了展望。
更新日期:2024-01-09
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