With the increasing average lifespan of human beings, the wear and tear caused by daily activities on joints will also escalate. Consequently, there is a growing focus on the development of green, environmentally friendly, and biocompatible non-toxic lubricating materials. The presence of dual chemical active centers in natural amino acids results in anions and cations that lead to precipitation and poor lubrication effects in traditional choline amino acid ionic liquids. In this study, nine types of choline acetyl-amino acid ionic liquids ([Ch][Ac-AA]ILs) were synthesized using acetylated amino acids (Ac-AA) as anions and choline (Ch) as cations. The physicochemical properties and tribological behavior of [Ch][Ac-AA]ILs at different frequencies were evaluated. The results demonstrated that [Ch][Ac-AA]ILs exhibited excellent tribological properties and maintained effective lubrication even under high-frequency friction conditions compared to sodium hyaluronate (HA-T). This performance was attributed to the carbon chain length and functional group composition of [Ch][Ac-AA]ILs' anions. Energy dispersive spectroscopy and X-ray photoelectron spectroscopy analysis revealed that the superior lubrication performance of [Ch][Ac-AA]ILs was associated with the formation of chemical reaction films and physical adsorption films on the surface of friction pairs. This research enriches our understanding of [Ch][AA]ILs-based lubrication systems while providing valuable insights for selecting joint lubricants suitable for different activity frequencies.

随着人类平均寿命的不断延长，日常活动对关节造成的磨损也会不断加剧。因此，绿色、环保、生物相容性无毒润滑材料的开发日益受到关注。天然氨基酸中双重化学活性中心的存在导致阴离子和阳离子的存在，导致传统胆碱氨基酸离子液体产生沉淀，润滑本研究以乙酰化氨基酸（Ac-AA）为阴离子、胆碱（Ch）为阳离子合成了九种胆碱乙酰氨基酸离子液体（[Ch][Ac-AA]ILs）。评估了不同频率下 [Ch][Ac-AA]IL 的物理化学性质和摩擦学行为。结果表明，与透明质酸钠 (HA-T) 相比，[Ch][Ac-AA]IL 表现出优异的摩擦学性能，即使在高频摩擦条件该性能归因于 [Ch][Ac-AA]IL 阴离子的碳链长度和官能团组成。能量色散谱和X射线光电子能谱分析表明，[Ch][Ac-AA]ILs优异的润滑性能与摩擦副表面化学反应膜和物理吸附膜的形成有关。这项研究丰富了我们对基于 [Ch][AA]ILs 的润滑系统的理解，同时为选择适合不同活动频率的关节润滑剂提供了宝贵的见解。