A Highly Chemically Robust 3D Interpenetrated MOF Heterogeneous Catalyst for the Synthesis of Hantzsch 1,4-Dihydropyridines and Drug Molecules,Small

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A Highly Chemically Robust 3D Interpenetrated MOF Heterogeneous Catalyst for the Synthesis of Hantzsch 1,4-Dihydropyridines and Drug Molecules
Small ( IF 13.0 ) Pub Date : 2024-01-08 , DOI: 10.1002/smll.202309281
Rupam Sahoo ₁ , Bikram Pramanik ₁ , Supriya Mondal ₁ , Madhab C Das ₁

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Metal–organic frameworks (MOFs) have attracted immense attention as efficient heterogeneous catalysts over other solid catalysts, however, their chemical environment instability often limits their catalytic potential. Herein, utilizing a flexible unexplored tetra-acid ligand and employing the mixed ligand approach, a 3D interpenetrated robust framework is strategically developed, IITKGP-51 (IITKGP stands for Indian Institute of Technology Kharagpur), which retained its crystallinity over a wide range of pH solution (4–12). Having ample open metal sites (OMSs), IITKGP-51 is explored as a heterogeneous catalyst in one-pot Hantzsch condensation reaction, with low catalyst loading for a broad range of substrates. The synthesis of drug molecules remains one of the most significant and emergent areas of organic and medicinal chemistry. Considering such practical utility, biologically important Nemadipine B and Nifedipine drug molecules (calcium channel protein inhibitor) are synthesized for the first time by using this catalyst and fully characterized via SC-XRD and other spectroscopic methods. This report inaugurates the usage of a MOF material as a catalyst for the synthesis of drug molecules.

中文翻译：

用于合成 Hantzsch 1,4-二氢吡啶和药物分子的高度化学稳定性的 3D 互穿 MOF 多相催化剂

金属有机框架（MOF）作为比其他固体催化剂更高效的多相催化剂而引起了极大的关注，然而，其化学环境的不稳定性往往限制了其催化潜力。在此，利用灵活的未开发的四酸配体并采用混合配体方法，战略性地开发了一种3D互穿的稳健框架IITKGP-51（IITKGP代表印度理工学院卡拉格普尔分校），它在很宽的pH范围内保持其结晶度解决方案（4-12）。 IITKGP-51具有充足的开放金属位点 (OMS)，可作为一锅 Hantzsch 缩合反应中的多相催化剂，且催化剂负载量低，适用于多种底物。药物分子的合成仍然是有机化学和药物化学最重要和最新兴的领域之一。考虑到这种实用性，首次使用该催化剂合成了具有重要生物学意义的Nemadipine B和Nifedipine药物分子（钙通道蛋白抑制剂），并通过SC-XRD和其他光谱方法进行了全面表征。该报告首次使用 MOF 材料作为药物分子合成的催化剂。

更新日期：2024-01-08

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