MALAT1 protects dormant tumor cells from immune elimination,Nature Cancer

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MALAT1 protects dormant tumor cells from immune elimination
Nature Cancer ( IF 23.5 ) Pub Date : 2024-01-09 , DOI: 10.1038/s43018-023-00682-0
Zhibin Zhang ₁ , Judy Lieberman ₂

Affiliation

Cancer cells seed distant tissues and remain dormant before re-entering the cell cycle to form metastases. How tumor dormancy is maintained and how cells exit dormancy is poorly understood. A study shows that the lncRNA MALAT1 reactivates dormant cancer cells by upregulating serpin protease inhibitors in tumor cells to evade CD8+ T cells.

中文翻译：

MALAT1 保护休眠肿瘤细胞免受免疫消除

癌细胞在远处组织播种并保持休眠状态，然后重新进入细胞周期形成转移。人们对肿瘤休眠如何维持以及细胞如何退出休眠知之甚少。一项研究表明，lncRNA MALAT1 通过上调肿瘤细胞中的丝氨酸蛋白酶抑制剂来逃避 CD8+ T 细胞，从而重新激活休眠的癌细胞。

更新日期：2024-01-09

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