Intelligent responsive copper-diethyldithiocarbamate-based multifunctional nanomedicine for photothermal-augmented synergistic cancer therapy,Journal of Materials Chemistry B

当前位置： X-MOL 学术 › J. Mater. Chem. B › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Intelligent responsive copper-diethyldithiocarbamate-based multifunctional nanomedicine for photothermal-augmented synergistic cancer therapy
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2024-01-08 , DOI: 10.1039/d3tb02491a
Xiangyu Meng _{1,

2} , Jiayi Wu _{1,

3} , Zunfu Hu _{1,

2} , Xiuwen Zheng _{1,

4}

Affiliation

The design of multifunctional nanomedicine through the combination of multimodal treatments to achieve the optimal antitumor effect is essential for cancer therapy. Herein, we design and develop a multifunctional theranostic nanoplatform using an iron ion-doxorubicin (DOX) nanoscale coordination polymer (Fe/DOX NCP) as a shell coating on the surface of polyvinyl pyrrolidone (PVP) stabilized copper-diethyldithiocarbamate nanoparticles (Cu(DDC)₂ NPs) for combined tumor chemo-/photothermal/chemodynamic therapy. The obtained Cu(DDC)₂@Fe/DOX NPs display pH/laser dual-responsive degradation behavior and also exhibit favorable photothermal performance. Under 808 nm laser irradiation, Cu(DDC)₂@Fe/DOX NPs can convert light into heat, which not only kills tumor cells via hyperthermia in photothermal therapy (PTT), but also accelerates the degradation of Fe/DOX NCPs to release Fe³⁺ and DOX. The liberated Fe³⁺ can be used to catalyze hydrogen peroxide via the Fenton reaction to produce highly toxic hydroxyl radicals (˙OH) in chemodynamic therapy (CDT). The released DOX and the exposed Cu(DDC)₂ can cause significant cell death in combined chemotherapy via a superimposed effect. In vitro and in vivo results prove that Cu(DDC)₂@Fe/DOX NPs with laser irradiation present remarkable anticancer performances in hyperthermia-enhanced chemo-/CDT. Therefore, this study provides a new strategy for highly efficient synergistic cancer therapy.

中文翻译：

用于光热增强协同癌症治疗的智能响应型二乙基二硫代氨基甲酸铜多功能纳米药物

通过结合多模式治疗来设计多功能纳米药物以达到最佳的抗肿瘤效果对于癌症治疗至关重要。在此，我们设计和开发了一种多功能治疗诊断纳米平台，使用铁离子-阿霉素（DOX）纳米级配位聚合物（Fe/DOX NCP）作为聚乙烯吡咯烷酮（PVP）稳定的铜-二乙基二硫代氨基甲酸酯纳米颗粒（Cu（DDC）表面的壳涂层) ₂ NP) 用于肿瘤化疗/光热/化学动力学联合治疗。所得的Cu(DDC) ₂ @Fe/DOX NPs表现出pH/激光双响应降解行为，并且还表现出良好的光热性能。在808 nm激光照射下，Cu(DDC) ₂ @Fe/DOX NPs可以将光转化为热，不仅可以在光热疗法（PTT）中通过高温杀死肿瘤细胞，而且可以加速Fe/DOX NCPs的降解，释放Fe ³⁺和阿霉素。释放的Fe ³⁺可用于通过芬顿反应催化过氧化氢，在化学动力学疗法（CDT）中产生剧毒的羟基自由基（˙OH）。释放的DOX和暴露的Cu(DDC) ₂可以通过叠加效应在联合化疗中导致显着的细胞死亡。体外和体内结果证明激光照射下的Cu(DDC) ₂ @Fe/DOX NPs在热疗增强化疗/CDT中表现出显着的抗癌性能。因此，本研究为高效协同癌症治疗提供了新策略。

更新日期：2024-01-08

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南