当前位置: X-MOL 学术Ophthalmol. Ther. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Analysis of Clinical Characteristics and Neuropeptides in Patients with Dry Eye with and without Chronic Ocular Pain after FS-LASIK
Ophthalmology and Therapy ( IF 2.6 ) Pub Date : 2024-01-08 , DOI: 10.1007/s40123-023-00861-3
Lu Zhao 1 , Yifan Zhou 1 , Hongyu Duan 1 , Yu Zhang 1 , Baikai Ma 1 , Tingting Yang 2 , Jiawei Chen 3 , Yueguo Chen 1 , Hong Qi 1, 3
Affiliation  

Introduction

Chronic ocular pain, particularly prevalent in patients with dry eye disease and post-femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) surgery, presents with unclear clinical characteristics and an undefined pathogenesis. In this study, we aimed to compare clinical characteristics and tear neuropeptide concentrations in patients with dry eye disease (DED) with and without chronic ocular pain following FS-LASIK, and investigate correlations between ocular pain, clinical characteristics, and tear neuropeptide levels.

Methods

Thirty-eight post–FS-LASIK patients with DED were assigned to two groups: those with chronic ocular pain and those without chronic ocular pain. Dry eye, ocular pain, and mental health-related parameters were evaluated using specific questionnaires and tests. The morphology of corneal nerves and dendritic cells (DCs) was evaluated by in vivo confocal microscopy. Function of corneal innervation was evaluated by corneal sensitivity. Concentrations of tear cytokines (interleukin [IL]-6, IL-23, IL-17A, and interferon-γ) and neuropeptides (α-melanocyte-stimulating hormone, neurotensin, β-endorphin, oxytocin, and substance P [SP]) were measured using the Luminex assay.

Results

Most patients with chronic ocular pain experienced mild to moderate pain; the most common types included stimulated pain (provoked by wind and light), burning pain, and pressure sensation. More severe dry eye (P < 0.001), anxiety symptoms (P = 0.026), lower Schirmer I test values (P = 0.035), lower corneal nerve density (P = 0.043), and more activated DCs (P = 0.041) were observed in patients with ocular pain. Tear concentrations of SP and oxytocin were significantly higher in patients with ocular pain (P = 0.001, P = 0.021, respectively). Furthermore, significant correlations were observed among ocular pain severity, SP, and anxiety levels.

Conclusions

Patients with DED after FS-LASIK who have chronic ocular pain show more severe ocular and psychological discomfort and higher tear levels of neuropeptides. Furthermore, ocular pain severity is correlated with tear SP levels.

Trial Registration

ClinicalTrials.gov identifier: NCT05600985.



中文翻译:


FS-LASIK术后伴有和不伴有慢性眼痛的干眼症患者临床特征及神经肽分析


 介绍


慢性眼痛,尤其常见于干眼病和飞秒激光辅助激光原位角膜磨镶术(FS-LASIK)手术后的患者,其临床特征不明确,发病机制不明确。在本研究中,我们旨在比较 FS-LASIK 后伴有或不伴有慢性眼痛的干眼病 (DED) 患者的临床特征和泪液神经肽浓度,并研究眼痛、临床特征和泪液神经肽水平之间的相关性。

 方法


38 名 FS-LASIK 术后患有 DED 的患者被分为两组:患有慢性眼痛的组和没有慢性眼痛的组。使用特定的问卷和测试评估干眼、眼痛和心理健康相关参数。通过体内共聚焦显微镜评估角膜神经和树突状细胞(DC)的形态。通过角膜敏感性评价角膜神经支配的功能。泪液细胞因子(白介素 [IL]-6、IL-23、IL-17A 和干扰素-γ)和神经肽(α-黑素细胞刺激激素、神经降压素、β-内啡肽、催产素和 P 物质 [SP])的浓度使用 Luminex 测定进行测量。

 结果


大多数慢性眼痛患者都经历轻度至中度疼痛;最常见的类型包括刺激性疼痛(由风和光引起)、烧灼痛和压力感。观察到更严重的干眼症( P < 0.001)、焦虑症状( P = 0.026)、较低的 Schirmer I 测试值( P = 0.035)、较低的角膜神经密度( P = 0.043)和更多的活化 DC( P = 0.041)眼痛患者。眼痛患者泪液中 SP 和催产素浓度显着较高(分别为P = 0.001、 P = 0.021)。此外,还观察到眼痛严重程度、SP 和焦虑水平之间存在显着相关性。

 结论


FS-LASIK 术后患有慢性眼痛的 DED 患者表现出更严重的眼部和心理不适以及更高的泪液神经肽水平。此外,眼痛的严重程度与泪液 SP 水平相关。

 试用注册


ClinicalTrials.gov 标识符:NCT05600985。

更新日期:2024-01-08
down
wechat
bug