<br>压电增强近红外光催化纳米异质结集成可注射生物聚合物水凝胶用于抗骨肉瘤和成骨联合治疗,Bioactive Materials

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压电增强近红外光催化纳米异质结集成可注射生物聚合物水凝胶用于抗骨肉瘤和成骨联合治疗
Bioactive Materials ( IF 18.0 ) Pub Date : 2024-01-06 , DOI: 10.1016/j.bioactmat.2024.01.003
Cairong Xiao ₁ , Renxian Wang _{2,

3} , Rumin Fu ₁ , Peng Yu ₁ , Jianxun Guo ₂ , Guangping Li ₂ , Zhengao Wang ₁ , Honggang Wang ₂ , Jingjun Nie ₂ , Weifeng Liu ₄ , Jinxia Zhai ₁ , Changhao Li ₅ , Chunlin Deng ₁ , Dafu Chen ₂ , Lei Zhou ₆ , Chengyun Ning ₁

Affiliation

在促进骨组织再生的同时防止局部肿瘤复发是骨肉瘤治疗的迫切需求。然而，传统光敏剂的治疗效果有限，并且缺乏骨骼再生的能力。在这里，基于超小的铋/钛酸锶纳米立方体（表示为 Bi/SrTiO）开发了一种压电-光纳米异质结构，实现了压电场驱动的快速电荷分离与表面等离子体共振耦合，以高效生成活性氧。这些杂交纳米治疗药物被整合到可注射的生物聚合物水凝胶中，在 NIR 和超声的联合照射下表现出出色的抗癌效果。使用患者来源的异种移植模型和胫骨骨肉瘤模型的研究表明，水凝胶在相应模型中实现肿瘤抑制，有效率分别为 98.6% 和 67.6%。此外，水凝胶在骨缺损区域具有良好的填充和保留能力，在轻度超声照射下通过极化和向细胞传递电刺激来发挥骨修复治疗效果。本研究为骨肉瘤的整体治疗和组织再生提供了全面且临床可行的策略。

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Piezo-enhanced near infrared photocatalytic nanoheterojunction integrated injectable biopolymer hydrogel for anti-osteosarcoma and osteogenesis combination therapy

Preventing local tumor recurrence while promoting bone tissue regeneration is an urgent need for osteosarcoma treatment. However, the therapeutic efficacy of traditional photosensitizers is limited, and they lack the ability to regenerate bone. Here, a piezo-photo nanoheterostructure is developed based on ultrasmall bismuth/strontium titanate nanocubes (denoted as Bi/SrTiO), which achieve piezoelectric field-driven fast charge separation coupling with surface plasmon resonance to efficiently generate reactive oxygen species. These hybrid nanotherapeutics are integrated into injectable biopolymer hydrogels, which exhibit outstanding anticancer effects under the combined irradiation of NIR and ultrasound. studies using patient-derived xenograft models and tibial osteosarcoma models demonstrate that the hydrogels achieve tumor suppression with efficacy rates of 98.6 % and 67.6 % in the respective models. Furthermore, the hydrogel had good filling and retention capabilities in the bone defect region, which exerted bone repair therapeutic efficacy by polarizing and conveying electrical stimuli to the cells under mild ultrasound radiation. This study provides a comprehensive and clinically feasible strategy for the overall treatment and tissue regeneration of osteosarcoma.

更新日期：2024-01-06

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