To investigate the clinical efficacy of beraprost sodium (BPS) in the treatment of chronic kidney disease (CKD). In this single-centre, prospective, controlled, single-blind study, 252 patients diagnosed with CKD and treated at the Affiliated Hospital of Xuzhou Medical University were enrolled from September 2018 to June 2021. All participants were randomised into three groups: the control, BPS 40 μg, and BPS 20 μg groups. Both treatment groups were administered conventional therapy for 6 months. Renal function in the three groups was measured and compared 3 and 6 months post-treatment. 1. Renal function in the BPS 20 μg and BPS 40 μg groups was better than that in the control group after 3 and 6 months of treatment. 2. After 3 months of treatment, the levels of serum creatinine (P = 0.043), cystatin C (P = 0.039), and 24 h urinary total protein (P = 0.041) in the BPS 40 μg group were significantly lower than those in the BPS 20 μg group, the eGFR (P = 0.046) level was higher than that in the BPS 20 μg group, and the index improvement rate was better than that in the BPS 20 μg group (P < 0.05). 3. After 6 months of treatment, the improvement in renal function in the BPS 20 μg group was close to that in the BPS 40 μg group (P > 0.05). BPS improved renal function, reduced urinary protein levels, and delayed CKD progression. The clinical efficacy of BPS in the 40 μg group was faster than that in the BPS 20 μg group. The long-term use of BPS is effective in patients with CKD.

中文翻译：

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贝前列素钠治疗慢性肾脏病的临床疗效：一项为期六个月的前瞻性研究


探讨贝前列素钠（BPS）治疗慢性肾脏病（CKD）的临床疗效。在这项单中心、前瞻性、对照、单盲研究中，2018 年 9 月至 2021 年 6 月期间，入组了 252 名诊断为 CKD 并在徐州医科大学附属医院接受治疗的患者。所有参与者被随机分为三组：对照组、对照组、对照组和对照组。 BPS 40 μg 和 BPS 20 μg 组。两个治疗组均接受常规治疗6个月。治疗后3个月和6个月测量并比较三组的肾功能。 1.治疗3个月和6个月后，BPS 20μg和BPS 40μg组的肾功能优于对照组。 2.治疗3个月后，BPS 40μg组的血清肌酐（P=0.043）、胱抑素C（P=0.039）和24小时尿总蛋白（P=0.041）水平显着低于BPS 40μg组BPS 20 μg 组的 eGFR（P = 0.046）水平高于 BPS 20 μg 组，且指标改善率优于 BPS 20 μg 组（P < 0.05）。 3.治疗6个月后，BPS 20μg组肾功能改善情况与BPS 40μg组接近（P>0.05）。 BPS 可改善肾功能、降低尿蛋白水平并延缓 CKD 进展。 40 μg 组中 BPS 的临床疗效快于 BPS 20 μg 组。长期使用 BPS 对 CKD 患者有效。