Stabilizing Organic Radical Anion in Water by Metal–Organic Frameworks with Enhanced Stability for NIR Photothermal Antibacterial Therapy,ACS Materials Letters

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Stabilizing Organic Radical Anion in Water by Metal–Organic Frameworks with Enhanced Stability for NIR Photothermal Antibacterial Therapy
ACS Materials Letters ( IF 9.6 ) Pub Date : 2024-01-05 , DOI: 10.1021/acsmaterialslett.3c01377
Zhongming Huang _{1,

2} , Yu Wang _{1,

2} , Yuliang Yang _{1,

2} , Yijian Gao _{1,

2} , Yu Luo _{1,

2} , Xiliang Li _{1,

2} , Ning Li _{1,

2} , Ying Liu _{1,

2} , Qi Zhao _{1,

2} , Shengliang Li _{1,

2} , Xiao-Hong Zhang ₃

Affiliation

Tremendous efforts have been made in the development of highly stable organic radicals, especially in water and at high temperatures. The development, as yet, is mainly restricted to the lack of a useful way. Here we report a water-dispersible metal–organic framework-stabilized organic radical anion with superior stability. By shielding in zeolitic imidazolate framework-8 (ZIF-8), the water-dispersed radical nanoparticles (ZIF-Radical NPs) achieve a 1770-fold improvement in radical stability compared with free TCNQ radical species in water. Moreover, ZIF-Radical NPs show good tolerance for harsh conditions. Upon 808 nm light irradiation, the ZIF-Radical NPs exhibit good photothermal conversion performances with a high stability. Nearly 100% killing efficiency toward both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus was also achieved by efficient photothermal antibacterial activity of ZIF-Radical NPs. This work offers a new way for the development of a stable radical material for near-infrared biomedical applications.

中文翻译：

通过金属有机框架稳定水中的有机自由基阴离子，增强近红外光热抗菌治疗的稳定性

人们在开发高度稳定的有机自由基方面付出了巨大的努力，特别是在水中和高温下。目前的发展主要受限于缺乏有效的途径。在这里，我们报道了一种具有优异稳定性的水分散性金属有机骨架稳定的有机自由基阴离子。通过屏蔽咪唑骨架 8 (ZIF-8)，水分散自由基纳米颗粒 (ZIF-Radical NP) 的自由基稳定性比水中游离 TCNQ 自由基物种提高了 1770 倍。此外，ZIF-Radical NP 对恶劣条件表现出良好的耐受性。在 808 nm 光照射下，ZIF-Radical NPs 表现出良好的光热转换性能和高稳定性。ZIF-Radical NP 的高效光热抗菌活性还实现了对革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌的近 100% 杀灭效率。这项工作为开发用于近红外生物医学应用的稳定自由基材料提供了一种新方法。

更新日期：2024-01-05

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