2-Oxo-4-cyano-1,2-dihydropyridine-3-carboxamides were synthesized. Their antiproliferative activity was studied. They were shown to inhibit slightly the growth of cell lines of lung cancer (a more pronounced tendency for lines A549/ATCC, NCI-H522, and HOP-62); colon cancer (more pronounced for line HCC-2998); brain cancer (for line SNB-19), melanoma (for lines UACC-62, SK-MEL-2, and MALME-3M); kidney cancer (for lines A498 and UO-31); and breast cancer (for lines HS 578T and T-47D).

中文翻译：

---

2-Oxo-4-Cyano-1,2-二氢吡啶-3-甲酰胺的合成及其抗增殖活性

合成了2-氧代-4-氰基-1,2-二氢吡啶-3-甲酰胺。研究了它们的抗增殖活性。它们被证明可以轻微抑制肺癌细胞系的生长（A549/ATCC、NCI-H522 和 HOP-62 系的趋势更明显）；结肠癌（HCC-2998 系更明显）；脑癌（针对 SNB-19 系）、黑色素瘤（针对 UACC-62、SK-MEL-2 和 MALME-3M 系）；肾癌（A498 和 UO-31 系）；和乳腺癌（针对 HS 578T 和 T-47D 系）。