Visible-Light Photoredox-Catalyzed Intermolecular α-Aminomethyl/Carboxylative Dearomatization of Indoles with CO2 and α-Aminoalkyl Radical Precursors,Organic Letters

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Visible-Light Photoredox-Catalyzed Intermolecular α-Aminomethyl/Carboxylative Dearomatization of Indoles with CO2 and α-Aminoalkyl Radical Precursors
Organic Letters ( IF 4.9 ) Pub Date : 2024-01-05 , DOI: 10.1021/acs.orglett.3c03755
Wanxu Gao ₁ , Qi Yang ₁ , Han Yang ₁ , Yang Yao ₁ , Junxue Bai ₁ , Jianwei Sun _{1,

2} , Song Sun ₁

Affiliation

Disclosed here is a visible-light photoredox-catalyzed intermolecular sequential α-aminomethyl/carboxylative dearomatization of indoles with CO₂ and α-aminoalkyl radical precursors, affording a series of functionalized indoline-3-carboxylic acids and lactams in good yields with high regioselectivity. This multicomponent reaction provides a green and facile method for the synthesis of diverse functionalized indolines by using CO₂ as the carboxylic and carbonyl source.

中文翻译：

可见光光氧化还原催化 CO2 和 α-氨基烷基自由基前体对吲哚进行分子间 α-氨基甲基/羧基化脱芳构化

本文公开了一种可见光光氧化还原催化的吲哚与CO ₂和α-氨基烷基自由基前体的分子间连续α-氨基甲基/羧基化脱芳构化反应，以良好的产率和高区域选择性提供一系列官能化的二氢吲哚-3-羧酸和内酰胺。该多组分反应为使用CO ₂作为羧基和羰基源合成多种功能化二氢吲哚提供了一种绿色简便的方法。

更新日期：2024-01-05

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