Biomimetic Self-Maturation Mineralization System for Enamel Repair,Advanced Materials

当前位置： X-MOL 学术 › Adv. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Biomimetic Self-Maturation Mineralization System for Enamel Repair
Advanced Materials ( IF 27.4 ) Pub Date : 2024-01-04 , DOI: 10.1002/adma.202311659
Chen Lei ₁ , Kai-Yan Wang ₁ , Yu-Xuan Ma ₁ , Dong-Xiao Hao ₁ , Yi-Na Zhu ₁ , Qian-Qian Wan ₁ , Jiang-Shan Zhang ₁ , Franklin R Tay ₂ , Zhao Mu ₃ , Li-Na Niu ₁

Affiliation

Enamel repair is crucial for restoring tooth function and halting dental caries. However, contemporary research often overlooks the retention of organic residues within the repair layer, which hinders the growth of dense crystals and compromises the properties of the repaired enamel. During the maturation of natural enamel, the organic matrix undergoes enzymatic processing to facilitate further crystal growth, resulting in a highly mineralized tissue. Inspired by this process, a biomimetic self-maturation mineralization system is developed, comprising ribonucleic acid-stabilized amorphous calcium phosphate (RNA-ACP) and ribonuclease (RNase). The RNA-ACP induces initial mineralization in the form of epitaxial crystal growth, while the RNase present in saliva automatically triggers a biomimetic self-maturation process. The mechanistic study further indicates that RNA degradation prompts conformational rearrangement of the RNA-ACP, effectively excluding the organic matter introduced earlier. This exclusion process promotes lateral crystal growth, resulting in the generation of denser enamel-like apatite crystals that are devoid of organic residues. This strategy of eliminating organic residues from enamel crystals enhances the mechanical and physiochemical properties of the repaired enamel. The present study introduces a conceptual biomimetic mineralization strategy for effective enamel repair in clinical practice and offers potential insights into the mechanisms of biomineral formation.

中文翻译：

用于牙釉质修复的仿生自熟矿化系统

牙釉质修复对于恢复牙齿功能和预防龋齿至关重要。然而，当代研究经常忽视修复层内有机残留物的保留，这阻碍了致密晶体的生长并损害了修复牙釉质的性能。在天然牙釉质的成熟过程中，有机基质经过酶处理以促进进一步的晶体生长，从而形成高度矿化的组织。受此过程的启发，开发了一种仿生自成熟矿化系统，包括核糖核酸稳定的无定形磷酸钙（RNA-ACP）和核糖核酸酶（RNase）。 RNA-ACP 以外延晶体生长的形式诱导初始矿化，而唾液中存在的 RNase 自动触发仿生自我成熟过程。机理研究进一步表明，RNA 降解促使 RNA-ACP 构象重排，有效排除了之前引入的有机物。这种排除过程促进横向晶体生长，从而产生更致密的釉质状磷灰石晶体，且不含有机残留物。这种消除牙釉质晶体中有机残留物的策略增强了修复牙釉质的机械和物理化学性能。本研究介绍了一种在临床实践中有效修复牙釉质的概念仿生矿化策略，并为生物矿物质形成机制提供了潜在的见解。

更新日期：2024-01-04

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南