<br>柔性、可生物降解和无线磁电纸，用于生物电植入物的简单原位个性化,Advanced Materials

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柔性、可生物降解和无线磁电纸，用于生物电植入物的简单原位个性化
Advanced Materials ( IF 27.4 ) Pub Date : 2024-01-04 , DOI: 10.1002/adma.202311154
Jun Kyu Choe ₁ , Suntae Kim ₁ , Ah-Young Lee ₁ , Cholong Choi ₁ , Jae-Hyeon Cho ₁ , Wook Jo ₁ , Myoung Hoon Song ₁ , Chaenyung Cha ₁ , Jiyun Kim _{1,

2}

Affiliation

提供电刺激的生物电子植入物为电疗中的传统药物提供了一种有吸引力的替代方案。然而，实现这些植入物的简单、快速且经济高效的个性化，以在独特的临床和物理场景中进行定制治疗，是一个巨大的挑战。由于需要确保安全性和最小侵入性，需要灵活性、生物相容性、轻便性、生物可降解性和无线刺激能力等基本属性，进一步加剧了这一挑战。在这里，介绍了一种灵活的、可生物降解的生物电子纸，具有均匀分布的无线刺激功能，可实现生物电子植入物的简单个性化。该生物电子纸协同结合了i）无铅磁电纳米颗粒（MEN），有助于响应外部磁场的电刺激，以及ii）灵活且可生物降解的纳米纤维（NF），可以实现MEN的定位，以实现高选择性刺激、氧气/营养物渗透、细胞方向调节和生物降解速率控制。显示了通过增强神经元样 PC12 细胞的神经元分化及其微观结构方向的可控性来进行体外无线电刺激的有效性。此外，通过使用简单的造纸技术（例如切割和折叠）创建各种 3D 宏观结构，显示了生物电子纸的可扩展性、设计灵活性和快速可定制性。该平台有望实现简单快速的个性化临时生物电子植入物，用于微创无线刺激疗法。

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Flexible, Biodegradable, and Wireless Magnetoelectric Paper for Simple In Situ Personalization of Bioelectric Implants

Bioelectronic implants delivering electrical stimulation offer an attractive alternative to traditional pharmaceuticals in electrotherapy. However, achieving simple, rapid, and cost-effective personalization of these implants for customized treatment in unique clinical and physical scenarios presents a substantial challenge. This challenge is further compounded by the need to ensure safety and minimal invasiveness, requiring essential attributes such as flexibility, biocompatibility, lightness, biodegradability, and wireless stimulation capability. Here, a flexible, biodegradable bioelectronic paper with homogeneously distributed wireless stimulation functionality for simple personalization of bioelectronic implants is introduced. The bioelectronic paper synergistically combines i) lead-free magnetoelectric nanoparticles (MENs) that facilitate electrical stimulation in response to external magnetic field and ii) flexible and biodegradable nanofibers (NFs) that enable localization of MENs for high-selectivity stimulation, oxygen/nutrient permeation, cell orientation modulation, and biodegradation rate control. The effectiveness of wireless electrical stimulation in vitro through enhanced neuronal differentiation of neuron-like PC12 cells and the controllability of their microstructural orientation are shown. Also, scalability, design flexibility, and rapid customizability of the bioelectronic paper are shown by creating various 3D macrostructures using simple paper crafting techniques such as cutting and folding. This platform holds promise for simple and rapid personalization of temporary bioelectronic implants for minimally invasive wireless stimulation therapies.

更新日期：2024-01-04

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