Mast cells (MCs) are important intermediates between the nervous and immune systems. The cardiac autonomic nervous system (CANS) crucially modulates cardiac electrophysiology and arrhythmogenesis, but whether and how MC-CANS neuroimmune interaction influences arrhythmia remain unclear. Our clinical data showed a close relationship between serum levels of MC markers and CANS activity, and then we use mast cell stabilizers (MCSs) to alter this MC-CANS communication. MCSs, which are well-known anti-allergic agents, could reduce the risk of ventricular arrhythmia (VA) after myocardial infarction (MI). RNA-sequencing (RNA-seq) analysis to investigate the underlying mechanism by which MCSs could affect the left stellate ganglion (LSG), a key therapeutic target for modulating CANS, showed that the IL-6 and γ-aminobutyric acid (GABA)-ergic system may be involved in this process. Our findings demonstrated that MCSs reduce VA risk along with revealing the potential underlying antiarrhythmic mechanisms.

肥大细胞（MC）是神经系统和免疫系统之间的重要中间体。心脏自主神经系统 (CANS) 对心脏电生理学和心律失常发生至关重要，但 MC-CANS 神经免疫相互作用是否以及如何影响心律失常仍不清楚。我们的临床数据显示 MC 标记物的血清水平与 CANS 活性之间存在密切关系，然后我们使用肥大细胞稳定剂 (MCS) 来改变这种 MC-CANS 通讯。 MCS 是众所周知的抗过敏药物，可以降低心肌梗塞 (MI) 后室性心律失常 (VA) 的风险。 RNA 测序 (RNA-seq) 分析旨在研究 MCS 影响左星状神经节 (LSG)（调节 CANS 的关键治疗靶点）的潜在机制，结果表明 IL-6 和 γ-氨基丁酸 (GABA)-能系统可能参与这个过程。我们的研究结果表明，MCS 可以降低 VA 风险，同时揭示潜在的抗心律失常机制。