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Dual-Modality Nanoprobe for Noninvasive Detection of Microthrombus after Cerebral Ischemia/Reperfusion
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2024-01-03 , DOI: 10.1021/acsanm.3c04459 Xiaoxuan Xu 1 , Tingting Xu 1 , Dongfang Liu 1 , Jie Ding 1 , Di Chang 1 , Jinbing Xie 1 , Shenghong Ju 1
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2024-01-03 , DOI: 10.1021/acsanm.3c04459 Xiaoxuan Xu 1 , Tingting Xu 1 , Dongfang Liu 1 , Jie Ding 1 , Di Chang 1 , Jinbing Xie 1 , Shenghong Ju 1
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The presence of cerebral ischemia/reperfusion (CI/R) poses a significant impediment to the complete restoration of neuronal functioning following the onset of ischemic stroke and the implementation of clinical thrombolytic treatments. The timely identification of microthrombus is crucial in the early recognition of microcirculatory complications and in facilitating informed clinical decisions. However, current assays, such as clinical pathological analysis and imaging detection, have not adequately met the requirements for intravital detection of microthrombus following CI/R. To address this limitation, this study introduces a dual-modality nanoprobe named GNC, specifically designed for intravital detection of fibrin-rich microthrombus. By combining high-temporal-resolution optical imaging and high-spatial-resolution magnetic resonance imaging, the GNC nanoprobe enables noninvasive real-time imaging of microthrombus at the nanoscale and guides subsequent therapeutic decisions. This innovative approach of the GNC nanoprobe showed great promise in the development of diagnostic and therapeutic tools for managing microthrombus following CI/R.
中文翻译：
双模态纳米探针用于脑缺血/再灌注后微血栓的无创检测
脑缺血/再灌注（CI/R）的存在对缺血性中风发作后神经元功能的完全恢复和临床溶栓治疗的实施构成了重大障碍。及时识别微血栓对于早期识别微循环并发症和促进明智的临床决策至关重要。然而，目前的临床病理分析和影像学检测等检测方法还不足以满足CI/R后微血栓活体检测的要求。为了解决这一局限性，本研究引入了一种名为 GNC 的双模态纳米探针，专门用于活体检测富含纤维蛋白的微血栓。通过结合高时间分辨率光学成像和高空间分辨率磁共振成像，GNC纳米探针能够在纳米尺度上对微血栓进行无创实时成像，并指导后续的治疗决策。GNC 纳米探针的这种创新方法在开发 CI/R 后管理微血栓的诊断和治疗工具方面显示出巨大的前景。
更新日期：2024-01-03
中文翻译：
双模态纳米探针用于脑缺血/再灌注后微血栓的无创检测
脑缺血/再灌注（CI/R）的存在对缺血性中风发作后神经元功能的完全恢复和临床溶栓治疗的实施构成了重大障碍。及时识别微血栓对于早期识别微循环并发症和促进明智的临床决策至关重要。然而，目前的临床病理分析和影像学检测等检测方法还不足以满足CI/R后微血栓活体检测的要求。为了解决这一局限性，本研究引入了一种名为 GNC 的双模态纳米探针，专门用于活体检测富含纤维蛋白的微血栓。通过结合高时间分辨率光学成像和高空间分辨率磁共振成像，GNC纳米探针能够在纳米尺度上对微血栓进行无创实时成像，并指导后续的治疗决策。GNC 纳米探针的这种创新方法在开发 CI/R 后管理微血栓的诊断和治疗工具方面显示出巨大的前景。
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