血液氧合器用聚砜和聚丙烯中空纤维膜的表征和比较评价,Journal of Applied Polymer Science

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血液氧合器用聚砜和聚丙烯中空纤维膜的表征和比较评价
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2024-01-03 , DOI: 10.1002/app.55121
Oğuz Orhun Teber _{1,

2} , Ayşegül Derya Altinay _{1,

3} , Seyed Ali Naziri Mehrabani _{1,

2} , Bihter Zeytuncu _{1,

4} , Esra Ateş‐Genceli ₃ , Ebru Dulekgurgen ₃ , Tansu Gölcez _{5,

6} , Yahya Yıldız ₇ , Kerem Pekkan ₈ , İsmail Koyuncu _{1,

2,

3}

Affiliation

血液氧合器用于在体外循环期间使氧气水平饱和并从体内去除二氧化碳。尽管天然肺是亲水性的，但商业使用的氧合器材料是疏水性的。表面疏水性削弱了血液相容性，长期与血液环境接触可能导致不同程度的血液活性。聚砜可被视为氧合器设计中的替代亲水材料。因此，可能会致力于开发亲水膜。本研究旨在探讨使用聚砜基微孔中空纤维膜实现血气转移的可行性，并将其与市售聚丙烯膜进行比较。报道了不同温度和流速操作条件下膜形态、表面亲水性、弯曲度、传质速率和材料性能的结构差异。聚砜膜的水接触角为81.3 °，而商用聚丙烯膜的水接触角为94.5 °。聚砜和聚丙烯膜的传质阻力（s/m）在25°C下经计算分别为4.8×10 ⁴和1.5×10 ⁴。将聚砜制成的模块与商用氧合器并联放置在心肺旁路回路中，测量血液样本中的pH、pO ₂、pCO _{2水平和代谢活动。}

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Characterization and comparative evaluation of polysulfone and polypropylene hollow fiber membranes for blood oxygenators

Blood oxygenators are used to saturate oxygen levels and remove carbon dioxide from the body during cardiopulmonary bypass. Although the natural lung is hydrophilic, commercially used oxygenator materials are hydrophobic. Surface hydrophobicity weakens blood compatibility, as long-term contact with the blood environment may lead to different degrees of blood activity. Polysulfone may be considered an alternative hydrophilic material in the design of oxygenators. Therefore, it may be directed toward developing hydrophilic membranes. This study aims to investigate the feasibility of achieving blood gas transfer with a polysulfone-based microporous hollow fiber membrane and compare it with the commercially available polypropylene membranes. Structural differences in the membrane morphology, surface hydrophilicity, tortuosity, mass transfer rate, and material properties under different operation conditions of temperature and flow rates are reported. The polysulfone membrane has a water contact angle of 81.3°, whereas a commercial polypropylene membrane is 94.5°. The mass transfer resistances (s/m) for the polysulfone and polypropylene membranes are calculated to be 4.8 × 10⁴ and 1.5 × 10⁴ at 25°C, respectively. The module made of polysulfone was placed in the cardiopulmonary bypass circuit in parallel with the commercial oxygenator, and pH, pO₂, pCO₂ levels, and metabolic activity were measured in blood samples.

更新日期：2024-01-03

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