The disintegration of tablets plays a crucial role in facilitating drug release, and disintegrants are used in tablet formulations to promote the disintegration process. This study aimed to explore and understand the impact of salt incorporation on tablet disintegratability. The study was designed to modulate the microenvironment temperature of tablets through dissolution of salts incorporated in the formulation, with the aim to facilitate tablet disintegration. It was observed that the incorporation of salts generally prolonged tablet disintegration. The impact of incorporating salts on tablet properties was both concentration-dependent and multi-factorial. The observed effect of salts on tablet disintegration was likely influenced by a combination of factors, including different properties of the salts, enhanced solubility of components, the temperature difference between the tablet and the disintegration medium, the expansion of air resulting from increased microenvironment temperature, and the competition for water between salts and disintegrants. These factors collectively contributed to the overall impact of salts on tablet disintegration.

片剂的崩解对于促进药物释放起着至关重要的作用，崩解剂在片剂配方中用于促进崩解过程。本研究旨在探索和了解盐掺入对片剂崩解性的影响。该研究旨在通过溶解配方中的盐来调节片剂的微环境温度，以促进片剂崩解。据观察，盐的掺入通常会延长片剂的崩解时间。掺入盐对片剂性质的影响既依赖于浓度又受多种因素影响。观察到的盐对片剂崩解的影响可能受到多种因素的影响，包括盐的不同性质、组分溶解度的增强、片剂和崩解介质之间的温差、微环境温度升高导致的空气膨胀、以及盐和崩解剂之间对水的竞争。这些因素共同影响了盐对片剂崩解的总体影响。