Postural orthostatic tachycardia syndrome (POTS) presents heterogeneously and is diagnosed when appropriate symptoms are present in conjunction with a heart rate increase of at least 30 beats-per-minute upon standing without orthostatic hypotension. Much of the current understanding of POTS is based on clinical expertise, particularly regarding POTS phenotypes and their potential role in targeting pharmacologic treatment. This study describes the symptom presentation of POTS by phenotypes at a subspecialty POTS clinic. Data was collected prospectively during clinical visits between April 17, 2014 and February 8, 2021. This data was abstracted retrospectively by chart review. Most of the 378 study participants were female (89.9%) with a mean age 23.0 ± 4.9 years. Lightheadedness was the most common (97.6%) symptom and the most disruptive of quality of life (29.9%). Patients reported substantial functional impairment across multiple life domains, with 3.0 ± 2.8 days lost and 4.7 ± 2.3 unproductive days per week. There were no differences in symptom presentation among POTS phenotypes. POTS phenotypes are not distinguishable based on symptoms alone; if phenotyping is sought, testing is necessary. Further research is needed in better classifying POTS phenotypes with the potential goal of tailoring treatment.

体位性直立性心动过速综合征 (POTS) 的表现多种多样，当出现适当的症状且站立时心率增加至少 30 次/分钟（无直立性低血压）时即可诊断。目前对 POTS 的理解大部分基于临床专业知识，特别是关于 POTS 表型及其在靶向药物治疗中的潜在作用。本研究通过 POTS 专科诊所的表型描述了 POTS 的症状表现。数据是在 2014 年 4 月 17 日至 2021 年 2 月 8 日的临床访视期间前瞻性收集的。这些数据是通过图表审查回顾性提取的。 378 名研究参与者中大多数为女性 (89.9%)，平均年龄为 23.0 ± 4.9 岁。头晕是最常见的症状 (97.6%)，也是对生活质量影响最大的症状 (29.9%)。患者报告多个生活领域存在严重功能障碍，每周损失 3.0 ± 2.8 天，以及 4.7 ± 2.3 天无生产力。 POTS 表型之间的症状表现没有差异。仅根据症状无法区分 POTS 表型；如果寻求表型分析，则需要进行测试。需要进一步研究来更好地对 POTS 表型进行分类，以实现定制治疗的潜在目标。