Enantioselective synthesis of spiro-N,O-ketals via iridium and Brønsted acid co-catalyzed asymmetric formal [4+2] cycloaddition,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Enantioselective synthesis of spiro-N,O-ketals via iridium and Brønsted acid co-catalyzed asymmetric formal [4+2] cycloaddition
Chemical Communications ( IF 4.3 ) Pub Date : 2024-01-03 , DOI: 10.1039/d3cc05923e
Xiang-Qi Xie ₁ , Xingguang Li ₁ , Pei-Nian Liu ₁

Affiliation

We present an iridium and Brønsted acid co-catalyzed enantioselective formal [4+2] cycloaddition reaction of cyclic enamides with 2-(1-hydroxyallyl)phenols. This method yields a wide range of N-unsubstituted spiro-N,O-ketals, with good efficiency (up to 94%) and excellent enantioselectivities (most >95% ee). The protocol features easy scale-up and facile product derivatization.

中文翻译：

铱和布朗斯台德酸共催化不对称形式[4+2]环加成对映选择性合成螺-N,O-缩酮

我们提出了铱和布朗斯台德酸共催化环状烯酰胺与 2-(1-羟基烯丙基)苯酚的对映选择性形式 [4+2] 环加成反应。该方法可产生多种N-未取代的螺-N , O-缩酮，具有良好的效率（高达 94%）和优异的对映选择性（大多数 >95% ee）。该方案具有易于放大和产品衍生化的特点。

更新日期：2024-01-03

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南