Accurate 3D models of the cochlea are useful tools for research in the relationship between the electrode array and nerve fibres. The internal geometry of the cochlear canal plays an important role in understanding and quantifying that relationship. Predicting the location and shapes of the geometry is done by measuring histologic sections and fitting equations that can be used to predict parameters that fully define the geometry. A parameter sensitivity analysis is employed to prove that the size and location of the spiral lamina are the characteristics that most influence current distribution along target nerve fibres. The proposed landmark prediction method more accurately predicts the location of the points defining the spiral lamina in the apical region of the cochlea than methods used in previous modelling attempts. Thus, this technique can be used to generate 2D geometries that can be expanded to 3D models when high-resolution imaging is not available.

精确的耳蜗 3D 模型是研究电极阵列和神经纤维之间关系的有用工具。耳蜗管的内部几何形状在理解和量化这种关系方面发挥着重要作用。预测几何形状的位置和形状是通过测量组织切片和拟合方程来完成的，这些方程可用于预测完全定义几何形状的参数。采用参数敏感性分析来证明螺旋层的尺寸和位置是对沿目标神经纤维的电流分布影响最大的特征。与之前的建模尝试中使用的方法相比，所提出的界标预测方法更准确地预测定义耳蜗顶端区域中的螺旋层的点的位置。因此，该技术可用于生成 2D 几何形状，当高分辨率成像不可用时，该几何形状可扩展到 3D 模型。