当前位置：
X-MOL 学术
›
ACS Appl. Polym. Mater.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Dynamic Disulfide Bond Regulated Tough Adhesion and On-Demand Debonding of the Albumin-Based Double Network Hydrogel to Diverse Substrates
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2024-01-03 , DOI: 10.1021/acsapm.3c02002 Ziqing Tang 1 , Zhao Liu 2 , Min You 1 , Haiyan Yin 1 , Hui Yu 1 , Xinlei Shi 1 , Jia Yang 2 , Gang Qin 2 , Lin Zhu 3 , Qiang Chen 1
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2024-01-03 , DOI: 10.1021/acsapm.3c02002 Ziqing Tang 1 , Zhao Liu 2 , Min You 1 , Haiyan Yin 1 , Hui Yu 1 , Xinlei Shi 1 , Jia Yang 2 , Gang Qin 2 , Lin Zhu 3 , Qiang Chen 1
Affiliation
|
The controllable tough adhesion of hydrogels and solid surfaces is essential for the development of soft-rigid hybrid medical devices. However, controllability is challenging for numerous tough adhesive hydrogels. Here, we develop a tough adhesion double network hydrogel based on bovine serum albumin and polyacrylamide (BSA/PAAm DN gel) with adjustable and robust adhesion toward diverse solid substrates because of the dynamic disulfide bonds (−S–S–). The albumin-based double network hydrogel simultaneously shows superior bulk toughness and interfacial toughness. To prepare the BSA/PAAm DN gel, the solid substrate is first modified with a silane coupling agent containing sulfhydryl, and then, the BSA/PAAm DN gel is in situ polymerized on the modified solid substrate. During the formation and destruction of disulfide bonds, the BSA/PAAm DN gel is attained between the surface of the hydrogel and modified solid substrates with reversible adhesion and on-demand debonding. The tough interfacial toughness of BSA/PAAm DN gel on diverse solid substrates exceeds 1000 J m–2, and the adhesion energy even reaches 5000 J m–2 for glass. This double network hydrogel based on the protein and polymer provides insights into the application of tough adhesion hydrogels for hybrid medical devices.
中文翻译：
动态二硫键调节白蛋白基双网络水凝胶对不同基材的坚韧粘附和按需脱粘
水凝胶和固体表面的可控坚韧粘附对于软硬混合医疗器械的开发至关重要。然而，对于许多坚韧的粘合水凝胶来说，可控性具有挑战性。在这里，我们开发了一种基于牛血清白蛋白和聚丙烯酰胺（BSA/PAAm DN 凝胶）的坚韧粘附双网络水凝胶，由于动态二硫键（−S–S–），对不同的固体基质具有可调节和强大的粘附力。基于白蛋白的双网络水凝胶同时表现出优异的体积韧性和界面韧性。为了制备BSA/PAAm DN凝胶，首先用含有巯基的硅烷偶联剂对固体基质进行修饰，然后将BSA/PAAm DN凝胶在修饰的固体基质上进行原位聚合。在二硫键的形成和破坏过程中，水凝胶表面和改性固体基质之间形成了具有可逆粘附和按需脱粘的BSA/PAAm DN凝胶。BSA/PAAm DN凝胶在多种固体基材上的坚韧界面韧性超过1000 J m –2，对玻璃的粘附能甚至达到5000 J m –2。这种基于蛋白质和聚合物的双网络水凝胶为混合医疗器械中坚韧粘附水凝胶的应用提供了见解。
更新日期：2024-01-03
中文翻译：
动态二硫键调节白蛋白基双网络水凝胶对不同基材的坚韧粘附和按需脱粘
水凝胶和固体表面的可控坚韧粘附对于软硬混合医疗器械的开发至关重要。然而，对于许多坚韧的粘合水凝胶来说，可控性具有挑战性。在这里，我们开发了一种基于牛血清白蛋白和聚丙烯酰胺（BSA/PAAm DN 凝胶）的坚韧粘附双网络水凝胶，由于动态二硫键（−S–S–），对不同的固体基质具有可调节和强大的粘附力。基于白蛋白的双网络水凝胶同时表现出优异的体积韧性和界面韧性。为了制备BSA/PAAm DN凝胶，首先用含有巯基的硅烷偶联剂对固体基质进行修饰，然后将BSA/PAAm DN凝胶在修饰的固体基质上进行原位聚合。在二硫键的形成和破坏过程中，水凝胶表面和改性固体基质之间形成了具有可逆粘附和按需脱粘的BSA/PAAm DN凝胶。BSA/PAAm DN凝胶在多种固体基材上的坚韧界面韧性超过1000 J m –2，对玻璃的粘附能甚至达到5000 J m –2。这种基于蛋白质和聚合物的双网络水凝胶为混合医疗器械中坚韧粘附水凝胶的应用提供了见解。
京公网安备 11010802027423号