Cobalt-Catalyzed Asymmetric Aza-Nozaki–Hiyama–Kishi (NHK) Reaction of α-Imino Esters with Alkenyl Halides,Angewandte Chemie International Edition

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Cobalt-Catalyzed Asymmetric Aza-Nozaki–Hiyama–Kishi (NHK) Reaction of α-Imino Esters with Alkenyl Halides
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-01-02 , DOI: 10.1002/anie.202316012
Tingting Xia ₁ , Yinhui Wu ₁ , Jiangtao Hu ₁ , Xianqing Wu ₁ , Jingping Qu ₁ , Yifeng Chen _{1,

2}

Affiliation

The cobalt-catalyzed aza-NHK (Nozaki–Hiyama–Kishi) reaction of ketimine has been realized to access diverse α-tertiary vinylic amino esters with excellent enantioselectivity and broad functional group tolerance. Notably, both configuration of alkenyl halide provides the same stereochemical outcome of chiral α-alkenyl quaternary amino ester, indicating that isomerization of alkenyl fragment might be involved in the catalytic cycle.

中文翻译：

钴催化 α-亚氨基酯与烯基卤化物的不对称 Aza-Nozaki-Hiyama-Kishi (NHK) 反应

钴催化的酮亚胺氮杂-NHK（Nozaki-Hiyama-Kishi）反应已实现，可得到多种具有优异对映选择性和广泛官能团耐受性的α-叔乙烯基氨基酯。值得注意的是，烯基卤化物的两种构型提供了与手性α-烯基季氨基酯相同的立体化学结果，表明烯基片段的异构化可能参与催化循环。

更新日期：2024-01-02

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