CAR macrophages on a fast track to solid tumor therapy,Nature Immunology

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CAR macrophages on a fast track to solid tumor therapy
Nature Immunology ( IF 27.7 ) Pub Date : 2024-01-02 , DOI: 10.1038/s41590-023-01696-7
Shifaa M Abdin _{1,

2} , Daniela Paasch _{1,

2} , Nico Lachmann _{1,

2,

3,

4,

5}

Affiliation

Expressing chimeric antigen receptors (CARs) in macrophages has led to promising results in preclinical and clinical work. Now, induced pluripotent stem cells have been combined with a second-generation CAR to achieve macrophage rewiring and to broaden the applicability of the approach to solid malignancies.

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