The protracted timeline of maturation is a major bottleneck in generating adult-like neurons from human pluripotent stem cells. We identify a combination of four chemicals that promotes neuronal maturation by repressing epigenetic factors that inhibit it and stimulating activity-dependent factors that promote it.

中文翻译：

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鉴定驱动人类神经元成熟的化学鸡尾酒


漫长的成熟时间表是从人类多能干细胞产生成体样神经元的主要瓶颈。我们确定了四种化学物质的组合，它们通过抑制抑制神经元成熟的表观遗传因子和刺激促进神经元成熟的活动依赖性因子来促进神经元成熟。