<br>深入了解细胞外聚合物 (EPS) 在抗生素抗性基因传播中的作用,Environmental Pollution

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深入了解细胞外聚合物 (EPS) 在抗生素抗性基因传播中的作用
Environmental Pollution ( IF 7.6 ) Pub Date : 2023-12-31 , DOI: 10.1016/j.envpol.2023.123285
Shengnan Li ₁ , Guoxiang Duan ₂ , Yucan Xi ₁ , Yuhao Chu ₁ , Fengxiang Li ₃ , Shih-Hsin Ho ₁

Affiliation

抗生素抗性基因（ARG）在水生环境中普遍存在。废水处理厂的排放是ARG 释放到环境中的一个重要点源。据报道，生物处理过程可能会增强而不是去除 ARG，因为它们存在于污泥中。生物技术过程中 ARG 的衰减已被深入研究，表明许多微生物可以分泌复杂的细胞外聚合物质 (EPS)。这些EPS可以作为微生物群落的多功能元素，涉及保护、结构、识别、粘附和生理等方面。这些方面可以影响微生物细胞与胞外ARG之间的相互作用，以及微生物细胞对胞外ARG的摄取，从而改变胞外ARG的转化能力。然而，EPS是否会影响ARG水平转移（ARG传播的主要过程之一）仍不清楚。鉴于这一知识差距，本综述深入了解了 EPS 在 ARG 传播中的作用；进一步分析了ARG的传播机制，总结了EPS的分子组成和功能特性；此外，还讨论了 EPS 如何影响 ARG 缓解，并总结了废水处理过程中影响 EPS 如何促进 ARG 的因素。这篇综述从机械层面对 EPS 在生物降解过程中控制 ARG 的运输和命运中的作用提供了全面的见解。

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Insights into the role of extracellular polymeric substances (EPS) in the spread of antibiotic resistance genes

Antibiotic resistance genes (ARG) are prevalent in aquatic environments. Discharge from wastewater treatment plants is an important point source of ARG release into the environment. It has been reported that biological treatment processes may enhance rather than remove ARG because of their presence in sludge. Attenuation of ARG in biotechnological processes has been studied in depth, showing that many microorganisms can secrete complex extracellular polymeric substances (EPS). These EPS can serve as multifunctional elements of microbial communities, involving aspects, such as protection, structure, recognition, adhesion, and physiology. These aspects can influence the interaction between microbial cells and extracellular ARG, as well as the uptake of extracellular ARG by microbial cells, thus changing the transformative capability of extracellular ARG. However, it remains unclear whether EPS can affect horizontal ARG transfer, which is one of the main processes of ARG dissemination. In light of this knowledge gap, this review provides insight into the role of EPS in the transmission of ARGs; furthermore, the mechanism of ARG spread is analyzed, and the molecular compositions and functional properties of EPS are summarized; also, how EPS influence ARG mitigation is addressed, and factors impacting how EPS facilitate ARG during wastewater treatment are summarized. This review provides comprehensive insights into the role of EPS in controlling the transport and fate of ARG during biodegradation processes at the mechanistic level.

更新日期：2023-12-31

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