<br>探索 Astrodaucus orientalis (L.) Drude：植物化学分析及其抗阿尔茨海默病和糖尿病的生物潜力,Chemistry & Biodiversity

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探索 Astrodaucus orientalis (L.) Drude：植物化学分析及其抗阿尔茨海默病和糖尿病的生物潜力
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2023-12-29 , DOI: 10.1002/cbdv.202301753
Hafize Yuca ₁ , Bilge Aydin ₂ , Songul Karakaya ₃ , Gamze Goger ₄ , Zeynebe Bingöl ₅ , Ayşe Civas ₆ , Mehmet Koca ₇ , Betül Demirci ₈ , Oksana Sytar ₉ , Ilhami Gulcin ₁₀ , Zuhal Guvenalp ₁

Affiliation

Department of Pharmacognosy, Ataturk University, Faculty of Pharmacy, Erzurum, 25240, Türkiye.
Department of Pharmacognosy, Erzincan Binali Yıldırım University, Faculty of Pharmacy, Erzincan, 24002, Türkiye.
Department of Pharmaceutical Botany, Ataturk University, Faculty of Pharmacy, Erzurum, 25240, Türkiye.
Department of Pharmacognosy, Afyonkarahisar Health University, Faculty of Pharmacy, Afyonkarahisar, 03030, Türkiye.
Department of Medical Services and Techniques, Gaziosmanpasa University, Vocational School of Health Services, Tokat, 60000, Türkiye.
Department of Pharmacy and Pharmaceutical Services, Igdir University, Igdir, 76400, Türkiye.
Department of Pharmaceutical Chemistry, Ataturk University, Faculty of Pharmacy, Erzurum, 25240, Türkiye.
Department of Pharmacognosy, Anadolu University, Faculty of Pharmacy, Eskisehir, 26470, Türkiye.
Department of Plant Physiology, Slovak University of Agriculture, Nitra, 94976, Slovak Republic.
Department of Chemistry, Ataturk University, Faculty of Science, Erzurum, 25240, Türkiye.

目前的研究对东方星龙不同部位的抗氧化、抗糖尿病、抗菌、抗胆碱酯酶以及人碳酸酐酶 I 和 II (hCA I 和 II) 同工酶抑制活性进行了研究。通过分子对接测定乙酸辛酯的乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）抑制活性。使用 LC-MS/MS 对特定次级代谢物进行定量评估。通过 GC-MS/MS 对精油的化学成分进行了检查。对植物的解剖学特征进行了彻底的探索。根部和果实中的酚类物质含量和 DPPH 抗氧化能力最高。水果精油对AChE的抑制作用最高（44.13±3.61%），而根二氯甲烷亚提取物对BChE的抑制作用最好（86.13±2.58%）。细胞质 hCA I 和 II 同工酶受到根油的有效抑制，IC ₅₀值分别为 1.974 和 2.207 μM。发现对热带念珠菌和克柔念珠菌菌株最有效的提取物是根部所有提取物/子提取物（水除外），MIC 值 160>μg/mL。桧烯 (29.4%)、α-蒎烯 (20.2%)；乙酸辛酯(54.3%)；月桂烯（28.0%）；辛酸辛酯（71.3%）分别是地上部分、根、花和果实的主要成分。花精油、水果二氯甲烷和乙酸乙酯表现出有效的α-葡萄糖苷酶抑制活性，IC ₅₀值分别为900、40和937 μg/mL。

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Exploring Astrodaucus orientalis (L.) Drude: Phytochemical Analysis and its Biological Potential Against Alzheimer's and Diabetes

In current study antioxidant, antidiabetic, antimicrobial, anticholinesterase, and human carbonic anhydrase I, and II (hCA I and II) isoenzymes inhibition activities of Astrodaucus orientalis different parts were investigated. Achetylcholinesterse (AChE) and butyrylcholinesterse (BChE) inhibitory activities of octyl acetate were determined via molecular docking. Quantitative assessment of specific secondary metabolites was conducted using LC-MS/MS. An examination of chemical composition of essential oils was carried out by GC-MS/MS. A thorough exploration of plant‘s anatomical characteristics was undertaken. The highest phenolics level and DPPH antioxidant capacity were seen in root and fruit. Fruit essential oil demonstrated the highest AChE inhibition (44.13±3.61 %), while root dichloromethane sub-extract had the best inhibition towards BChE (86.13±2.58 %). Cytosolic hCA I, and II isoenzymes were influentially inhibited by root oil with 1.974 and 2.207 μM IC₅₀ values, respectively. The most effective extracts were found to be root all extract/sub-extracts (except water) against C. tropicalis and C. krusei strains with MIC value 160>μg/mL. Sabinene (29.4 %), α-pinene (20.2 %); octyl acetate (54.3 %); myrcene (28.0 %); octyl octanoate (71.3 %) were found principal components of aerial parts, roots, flowers, and fruits, respectively. Flower essential oil, fruit dicloromethane and ethyl acetate exhibited potent α-glucosidase inhibitory activity with 900, 40, and 937 μg/mL IC₅₀ values, respectively.

更新日期：2023-12-29

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