Numb chin syndrome is a rare pain disorder characterized by decreased sensation and paresthesia in the territory of the mental nerve. Neuropathic pain is sometimes described in this setting, and the most common treatments include oral analgesics, gabapentinoids, and carbamazepine; however, botulinum toxin type A has never been used in this setting. We describe a case of bilateral numb chin syndrome, secondary to Burkitt lymphoma, associated with refractory and persistent burning neuropathic pain, effectively treated twelve times with subcutaneous Botulinum toxin type A (BoNT/A) injections. The procedure was well tolerated, but the patient reported incomplete mouth closure of minimal entity. BoNT/A could be a safe and effective therapy for neuropathic pain associated with numb chin syndrome.

下巴麻木综合症是一种罕见的疼痛疾病，其特征是精神神经区域的感觉减退和感觉异常。有时在这种情况下会描述神经性疼痛，最常见的治疗方法包括口服镇痛药、加巴喷丁和卡马西平；然而，A 型肉毒杆菌毒素从未在这种情况下使用过。我们描述了一例继发于伯基特淋巴瘤的双侧下巴麻木综合征病例，伴有难治性和持续性烧灼性神经性疼痛，通过皮下 A 型肉毒杆菌毒素 (BoNT/A) 注射有效治疗了 12 次。该手术耐受性良好，但患者报告最小实体的口腔闭合不完全。 BoNT/A 可能是治疗与下巴麻木综合征相关的神经性疼痛的一种安全有效的疗法。