Rotundic Acid 及其衍生物作为有前途的天然抗癌三萜类化合物的功效：基于文献的研究,Chemistry & Biodiversity

当前位置： X-MOL 学术 › Chem. Biodivers. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Rotundic Acid 及其衍生物作为有前途的天然抗癌三萜类化合物的功效：基于文献的研究
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2023-12-27 , DOI: 10.1002/cbdv.202301492
Md. Shimul Bhuia ₁ , Raihan Chowdhury ₁ , Fatema Akter Sonia ₁ , Shrabonti Biswas ₁ , Jannatul Ferdous ₂ , Heba A. S. El-Nashar ₃ , Mohamed El-Shazly ₄ , Muhammad Torequl Islam ₁

Affiliation

Rotundic Acid (RA) 是一种天然存在的五环三萜，具有多种药理活性。本研究的主要重点是总结 RA 及其衍生物的抗癌特性、潜在机制以及药代动力学特征。通过在不同学术搜索引擎（包括 PubMed、Springer Link、Scopus、Wiley Online、Web of Science、ScienceDirect 和 Google Scholar）中搜索，从各种可靠且真实的文献中收集数据（截至 2023 年 11 月 10 日）。研究结果表明，RA 及其合成衍生物在各种临床前药理学测试系统中对乳腺癌、结直肠癌、肝癌和宫颈癌具有良好的抗癌特性。结果还表明，RA及其衍生物通过多种细胞机制表现出抗癌作用，包括细胞凋亡、抑制氧化应激、抗炎作用、细胞毒性、细胞周期阻滞、抗增殖作用、抗血管生成作用、并抑制癌细胞的迁移和侵袭。有人提出RA及其衍生化合物有能力作为一种有希望的化疗药物，因此需要进一步广泛的临床研究。

"点击查看英文标题和摘要"

Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature-Based Study

Rotundic acid (RA) is a naturally occurring pentacyclic triterpene with a multitude of pharmacological activities. The primary emphasis of this study is on summarizing the anticancer properties with the underlying mechanisms of RA and its derivatives, as well as the pharmacokinetic features. Data was collected (up to date as of November 10, 2023) from various reliable and authentic literatures by searching in different academic search engines, including PubMed, Springer Link, Scopus, Wiley Online, Web of Science, ScienceDirect, and Google Scholar. The findings imply that RA and its synthetic derivatives possess promising anti-cancer properties against breast, colorectal, liver, and cervical cancers in various preclinical pharmacological test systems. The results also indicate that RA and its derivatives demonstrated anticancer effects via a number of cellular mechanisms, including apoptotic cell death, inhibition of oxidative stress, anti-inflammatory effect, cytotoxicity, cell cycle arrest, anti-proliferative effect, anti-angiogenic effect, and inhibition of cancer cell migration and invasion. It has been proposed that RA and its derived compounds have the capability to serve as a hopeful chemotherapeutic agent, so further extensive clinical research is necessary.

更新日期：2023-12-27

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>