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1,3,4-Thiadiazole: A Versatile Scaffold for Drug Discovery
Letters in Organic Chemistry ( IF 0.7 ) Pub Date : 2023-12-22 , DOI: 10.2174/0115701786274678231124101033
Ravi K. Mittal 1 , Raghav Mishra 2 , Vikram Sharma 1 , Isha Mishra 1
Affiliation  

1,3,4-Thiadiazole has garnered considerable attention in the scientific community due to its captivating molecular structure and ability to serve as a foundation for creating novel pharmaceutical compounds. Numerous medications feature the 1,3,4-thiadiazole ring in their chemical structure, highlighting its relevance and efficacy in pharmaceutical research and development. The key objective of this comprehensive review is to provide an understandable overview of the chemistry and diverse pharmacological activities associated with 1,3,4-thiadiazole compounds. The manuscript was compiled by conducting a thorough literature review, which included an in-depth analysis of globally esteemed scientific research databases. The remarkable chemical characteristics and diverse pharmacological impacts of 1,3,4-Thiadiazole highlight its significant potential as a structural scaffold for the development of novel therapeutic substances. Based on the information available on synthetic molecules that incorporate the 1,3,4-thiadiazole framework and their wide range of uses, it is reasonable to expect significant advancements in the near future and the possibility of employing these compounds in different domains.

中文翻译:

1,3,4-噻二唑:药物发现的多功能支架

1,3,4-噻二唑因其迷人的分子结构和作为创造新型药物化合物的基础的能力而在科学界引起了相当大的关注。许多药物的化学结构中都含有 1,3,4-噻二唑环,突出了其在药物研究和开发中的相关性和功效。本次综合综述的主要目的是提供与 1,3,4-噻二唑化合物相关的化学和多种药理活性的易于理解的概述。该手稿是通过彻底的文献综述编写的,其中包括对全球知名科学研究数据库的深入分析。 1,3,4-噻二唑显着的化学特性和多样化的药理作用凸显了其作为开发新型治疗物质的结构支架的巨大潜力。根据有关包含 1,3,4-噻二唑骨架的合成分子及其广泛用途的现有信息,可以合理地预期在不久的将来会取得重大进展,并且有可能在不同领域中使用这些化合物。
更新日期:2023-12-22
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