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Designing stable humanized antibodies
Nature Biomedical Engineering ( IF 26.8 ) Pub Date : 2023-12-27 , DOI: 10.1038/s41551-023-01168-1
Alissa M Hummer 1 , Charlotte M Deane 1
Affiliation  

Humanized versions of antibodies with enhanced stability can be designed via the systematic energy-based ranking of computationally grafted non-human complementarity-determining regions onto thousands of human frameworks.

中文翻译:


设计稳定的人源化抗体



通过对计算移植的非人类互补性决定区域到数千个人类框架上进行基于能量的系统排序,可以设计具有增强稳定性的人源化抗体版本。
更新日期:2023-12-27
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