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Durable Immunomodulatory Nanofiber Niche for the Functional Remodeling of Cardiovascular Tissue
ACS Nano ( IF 15.8 ) Pub Date : 2023-12-26 , DOI: 10.1021/acsnano.3c09692 Yonghang Liu 1 , Liren Wang 2 , Zhuo Liu 3 , Yuhao Kang 2 , Tianhui Chen 4 , Chen Xu 3 , Tonghe Zhu 1
ACS Nano ( IF 15.8 ) Pub Date : 2023-12-26 , DOI: 10.1021/acsnano.3c09692 Yonghang Liu 1 , Liren Wang 2 , Zhuo Liu 3 , Yuhao Kang 2 , Tianhui Chen 4 , Chen Xu 3 , Tonghe Zhu 1
Affiliation
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Functional remodeling and prolonged anti-inflammatory responses are both vital for repairing damage in the cardiovascular system. Although these aspects have each been studied extensively alone, attempts to fabricate scaffolds that combine these effects have seen limited success. In this study, we synthesized salvianic acid A (SA, danshensu) blocked biodegradable polyurethane (PCHU-D) and enclosed it within electrospun nanofibers to synthesize a durable immunomodulatory nanofiber niche (DINN), which provided sustained SA release during inflammation. Given its excellent processability, mechanical properties, and shape memory function, we developed two variants of the DINN as vascular scaffolds and heart patches. Both these variants exhibited outstanding therapeutic effects in in vivo experiments. The DINN was expertly designed such that it gradually decomposes along with SA release, substantially facilitating cellular infiltration and tissue remodeling. Therefore, the DINN effectively inhibited the migration and chemotaxis of inflammatory cells, while also increasing the expression of angiogenic genes. As a result, it promoted the recovery of myocardial function after myocardial infarction and induced rapid reendothelialization following arterial orthotopic transplantation repair. These excellent characteristics indicate that the DINN holds great potential as a multifunctional agent for repairing cardiovascular tissues.
中文翻译：
用于心血管组织功能重塑的耐用免疫调节纳米纤维利基
功能重塑和延长抗炎反应对于修复心血管系统损伤都至关重要。尽管这些方面都已被单独广泛研究，但制造结合这些效应的支架的尝试取得了有限的成功。在这项研究中，我们合成了丹酚酸A（SA，danshensu）封闭的可生物降解聚氨酯（PCHU-D），并将其封装在电纺纳米纤维中，以合成耐用的免疫调节纳米纤维生态位（DINN），在炎症过程中提供持续的SA释放。鉴于其优异的加工性能、机械性能和形状记忆功能，我们开发了 DINN 的两种变体作为血管支架和心脏补片。这两种变体在体内实验中都表现出出色的治疗效果。 DINN 经过专业设计，随着 SA 释放而逐渐分解，大大促进细胞浸润和组织重塑。因此，DINN有效抑制炎症细胞的迁移和趋化性，同时还增加血管生成基因的表达。结果，它促进了心肌梗塞后心肌功能的恢复，并诱导动脉原位移植修复后的快速再内皮化。这些优异的特性表明 DINN 作为修复心血管组织的多功能药物具有巨大的潜力。
更新日期：2023-12-26
中文翻译：
用于心血管组织功能重塑的耐用免疫调节纳米纤维利基
功能重塑和延长抗炎反应对于修复心血管系统损伤都至关重要。尽管这些方面都已被单独广泛研究，但制造结合这些效应的支架的尝试取得了有限的成功。在这项研究中，我们合成了丹酚酸A（SA，danshensu）封闭的可生物降解聚氨酯（PCHU-D），并将其封装在电纺纳米纤维中，以合成耐用的免疫调节纳米纤维生态位（DINN），在炎症过程中提供持续的SA释放。鉴于其优异的加工性能、机械性能和形状记忆功能，我们开发了 DINN 的两种变体作为血管支架和心脏补片。这两种变体在体内实验中都表现出出色的治疗效果。 DINN 经过专业设计，随着 SA 释放而逐渐分解，大大促进细胞浸润和组织重塑。因此，DINN有效抑制炎症细胞的迁移和趋化性，同时还增加血管生成基因的表达。结果，它促进了心肌梗塞后心肌功能的恢复，并诱导动脉原位移植修复后的快速再内皮化。这些优异的特性表明 DINN 作为修复心血管组织的多功能药物具有巨大的潜力。
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