Body Fat Depletion: the Yin Paradigm for Treating Type 2 Diabetes,Current Atherosclerosis Reports

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Body Fat Depletion: the Yin Paradigm for Treating Type 2 Diabetes
Current Atherosclerosis Reports ( IF 5.7 ) Pub Date : 2023-12-27 , DOI: 10.1007/s11883-023-01181-4
Jingjing Zhu _{1,

2,

3} , John P H Wilding _{2,

3}

Affiliation

Purpose of Review

To highlight that body fat depletion (the Yin paradigm) with glucose-lowering treatments (the Yang paradigm) are associated with metabolic benefits for patients with type 2 diabetes mellitus (T2DM).

Recent Findings

The sodium-glucose cotransporter-2 inhibitor-mediated sodium/glucose deprivation can directly improve glycemic control and kidney outcome in patients with T2DM. The glucose deprivation might also promote systemic fatty acid β-oxidation to deplete ectopic/visceral fat and thereby contribute to the prevention of cardiovascular diseases. As with metabolic surgery, bioengineered incretin-based medications with potent anorexigenic and insulinotropic efficacy can significantly reduce blood glucose as well as body weight (especially in the ectopic/visceral fat depots). The latter effects could be a key contributor to their cardiovascular-renal protective effects.

Summary

In addition to a healthy diet, the newer glucose-lowering medications, with body fat reduction effects, should be prioritized when treating patients with T2DM, especially for those with established cardiovascular/renal risks or diseases.

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