A Janus Gelatin Sponge with a Procoagulant Nanoparticle-Embedded Surface for Coagulopathic Hemostasis,ACS Applied Materials & Interfaces

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A Janus Gelatin Sponge with a Procoagulant Nanoparticle-Embedded Surface for Coagulopathic Hemostasis
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-12-26 , DOI: 10.1021/acsami.3c15517
Yu Wang _{1,

2} , Jie Lin _{1,

2} , Hao Fu _{1,

2} , Bingran Yu _{1,

2} , Guochao Zhang ₃ , Yang Hu _{1,

2} , Fu-Jian Xu _{1,

2}

Affiliation

Apart from the wide and safe application of natural polymer-based hemostatic materials/devices, it is still desirable to develop new types of hemostatic materials that can achieve both potent coagulopathic hemostasis and a facile preparation process. In this work, one Janus gelatin sponge (J-ZGS) is readily constructed for both coagulation-dependent and coagulopathic hemostasis by embedding zein nanoparticles on the surface of a self-prepared gelatin sponge (S-GS): zein nanoparticles were facilely prepared by an antisolvent method to achieve procoagulant blood–material interactions, while S-GS was prepared by freeze-drying a foaming gelatin solution. Due to the distinct secondary structure, the optimal zein nanoparticles possessed a higher in vitro hemostatic property than the pristine zein powder and other nanoparticles, the underlying mechanism of which was revealed as the superior RBC/platelet adhesion property in the presence/absence of plasma proteins. Compared with S-GS and a commercial gelatin sponge, J-ZGS achieved a significantly higher in vitro hemostatic property and similarly good blood compatibility/cytocompatibility. Moreover, in vivo artery-injury models confirmed the outstanding hemostatic performance of J-ZGS under both coagulation-dependent and coagulopathic conditions. Our work offers an appealing approach for developing potent hemostatic sponges from natural polymer-based nanoparticles that could be further extended to versatile hemostatic materials for coagulopathic hemostasis.

中文翻译：

具有促凝血纳米颗粒嵌入表面的 Janus 明胶海绵，用于凝血止血

除了天然聚合物止血材料/装置的广泛和安全应用之外，仍然需要开发能够实现有效凝血止血和简便制备工艺的新型止血材料。在这项工作中，通过将玉米醇溶蛋白纳米颗粒嵌入自制明胶海绵（S-GS）的表面，可以轻松构建一种 Janus 明胶海绵（J-ZGS），用于凝血依赖性止血和凝血病止血：玉米醇溶蛋白纳米颗粒通过以下方法轻松制备：一种反溶剂方法来实现促凝血液与材料的相互作用，而 S-GS 是通过冷冻干燥发泡明胶溶液来制备的。由于独特的二级结构，最佳的玉米醇溶蛋白纳米颗粒比原始玉米醇溶蛋白粉末和其他纳米颗粒具有更高的体外止血性能，其潜在机制被揭示为在存在/不存在血浆蛋白的情况下优越的红细胞/血小板粘附性能。与S-GS和市售明胶海绵相比，J-ZGS具有显着更高的体外止血性能和同样良好的血液相容性/细胞相容性。此外，体内动脉损伤模型证实了 J-ZGS 在凝血依赖性和凝血障碍条件下均具有出色的止血性能。我们的工作提供了一种有吸引力的方法，可以利用基于天然聚合物的纳米粒子开发有效的止血海绵，该方法可以进一步扩展到用于凝血止血的多功能止血材料。

更新日期：2023-12-26

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