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Rapid Preparation of Highly Stretchable and Fast Self-Repairing Antibacterial Hydrogels for Promoting Hemostasis and Wound Healing
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2023-12-27 , DOI: 10.1021/acsabm.3c00969
Wei Wang 1 , Zhengdong Yuan 2 , Ting Li 1 , Yang Wang 1 , Kaiwen Zhang 2 , Junjie Wu 2 , Shiru Zhang 1 , Fenglai Yuan 2 , Weifu Dong 1
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2023-12-27 , DOI: 10.1021/acsabm.3c00969
Wei Wang 1 , Zhengdong Yuan 2 , Ting Li 1 , Yang Wang 1 , Kaiwen Zhang 2 , Junjie Wu 2 , Shiru Zhang 1 , Fenglai Yuan 2 , Weifu Dong 1
Affiliation
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Hydrogel dressings have emerged as a vital resource in wound management, offering several advantages over conventional wound dressing materials. Their inherent biocompatibility, ability to replicate the native extracellular matrix, and capacity to provide an ideal environment for cell survival make them particularly valuable. Nevertheless, the mechanical properties of many hydrogel dressings are an area that warrants improvement, as it currently constrains their application range. This limitation is especially evident when skin wounds are addressed in highly active or easily scratched areas. In this study, we present the development of a highly stretchable self-repairing hydrogel by cross-linking poly(vinyl alcohol) (PVA) through dynamic boron ester bonds, coupled with the hydrogen bonding of carboxymethyl cellulose sodium (CMC) via an efficient one-pot method without adding any catalyst. This innovative PVA/CMC hydrogel exhibited remarkable antibacterial properties achieved through the incorporation of bergamot oil, which was dispersed in a β-cyclodextrin solution. The hydrogel’s elongation at the point of rupture reached an impressive 1910%, and it was capable of rapid self-healing in just 3 min upon bonding. Additionally, the hydrogel demonstrated excellent hemostatic properties, effectively mitigating blood loss and exudation. In vivo wound models have shown that PVA/CMC significantly expedites wound healing by reducing bacterial infections, inflammatory responses, and blood loss and by promoting collagen deposition. In summary, this research provides crucial insights into its potential as an advanced wound dressing material, particularly well-suited for addressing wounds in places with frequent activities or easy scratches.
中文翻译：
快速制备高拉伸、快速自我修复的抗菌水凝胶以促进止血和伤口愈合
水凝胶敷料已成为伤口处理的重要资源，与传统伤口敷料材料相比具有多种优势。它们固有的生物相容性、复制天然细胞外基质的能力以及为细胞生存提供理想环境的能力使它们特别有价值。然而，许多水凝胶敷料的机械性能是一个值得改进的领域，因为它目前限制了它们的应用范围。当在高度活跃或容易抓伤的区域处理皮肤伤口时，这种限制尤其明显。在这项研究中，我们开发了一种高度可拉伸的自修复水凝胶，通过动态硼酯键交联聚乙烯醇（PVA），并通过有效的氢键与羧甲基纤维素钠（CMC）结合。 -锅法，不添加任何催化剂。这种创新的 PVA/CMC 水凝胶通过加入分散在 β-环糊精溶液中的佛手柑油而表现出卓越的抗菌特性。该水凝胶在断裂点的伸长率达到了令人印象深刻的1910%，并且在粘合后能够在短短3分钟内快速自愈。此外，水凝胶表现出优异的止血性能，有效减少失血和渗出。体内伤口模型表明，PVA/CMC 通过减少细菌感染、炎症反应和失血以及促进胶原蛋白沉积，显着加快伤口愈合。总之，这项研究为其作为先进伤口敷料材料的潜力提供了重要的见解，特别适合处理经常活动或容易划伤的地方的伤口。
更新日期：2023-12-27
中文翻译：
快速制备高拉伸、快速自我修复的抗菌水凝胶以促进止血和伤口愈合
水凝胶敷料已成为伤口处理的重要资源，与传统伤口敷料材料相比具有多种优势。它们固有的生物相容性、复制天然细胞外基质的能力以及为细胞生存提供理想环境的能力使它们特别有价值。然而，许多水凝胶敷料的机械性能是一个值得改进的领域，因为它目前限制了它们的应用范围。当在高度活跃或容易抓伤的区域处理皮肤伤口时，这种限制尤其明显。在这项研究中，我们开发了一种高度可拉伸的自修复水凝胶，通过动态硼酯键交联聚乙烯醇（PVA），并通过有效的氢键与羧甲基纤维素钠（CMC）结合。 -锅法，不添加任何催化剂。这种创新的 PVA/CMC 水凝胶通过加入分散在 β-环糊精溶液中的佛手柑油而表现出卓越的抗菌特性。该水凝胶在断裂点的伸长率达到了令人印象深刻的1910%，并且在粘合后能够在短短3分钟内快速自愈。此外，水凝胶表现出优异的止血性能，有效减少失血和渗出。体内伤口模型表明，PVA/CMC 通过减少细菌感染、炎症反应和失血以及促进胶原蛋白沉积，显着加快伤口愈合。总之，这项研究为其作为先进伤口敷料材料的潜力提供了重要的见解，特别适合处理经常活动或容易划伤的地方的伤口。
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