完全基于天然成分的坚韧且生物相容的水凝胶组织粘合剂,ACS Applied Polymer Materials

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完全基于天然成分的坚韧且生物相容的水凝胶组织粘合剂
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2023-12-26 , DOI: 10.1021/acsapm.3c01926
Ziyi Xu ₁ , Haihui Zhang ₂ , Yuan Huang ₁ , Hao Zhong ₁ , Peiwu Qin ₂ , Sibo Cheng ₃ , Yuenan Wang ₄ , Canhui Yang ₁

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水凝胶组织粘合剂在生物工程中具有巨大的潜在应用。现有的水凝胶组织粘合剂通常不能同时具有足够的机械强度和可接受的生物相容性。在此，我们报告了一种一步法来合成完全由天然成分制成的坚韧且生物相容的水凝胶组织粘合剂。我们选择两种天然聚合物（壳聚糖和明胶）来构建主链，并选择生物源化合物京尼平作为交联剂。我们发现，凝胶化后，京尼平会交联壳聚糖和明胶，形成两个互穿网络并将它们与组织表面互连。同时，在基质中形成氢键以加强网络，并在界面处形成氢键以加强水凝胶和组织之间的粘附。此外，我们精心利用高初始聚合物含量来诱导聚合物网络中的拓扑缠结，从而增韧水凝胶。所得的壳聚糖-明胶水凝胶提供了坚韧的基质，强大的共价互连和氢键提供了强大的界面，实现了~190 kPa的拉伸强度，205.7 J/m 2 的断裂韧性^， 197.6的I型粘附能。 J/m ²，II型粘附能为51.2J/m ²。我们证明水凝胶组织粘合剂是可注射、可降解且无细胞毒性的，可用于抗癌药物顺铂的控释。基于全天然成分的坚韧和生物相容性水凝胶有望作为生物医学和相关应用的组织粘合剂。

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Tough and Biocompatible Hydrogel Tissue Adhesives Entirely Based on Naturally Derived Ingredients

Hydrogel tissue adhesives have tremendous potential applications in biological engineering. Existing hydrogel tissue adhesives generally do not have adequate mechanical robustness and acceptable biocompatibility at the same time. Herein, we report a one-step method to synthesize tough and biocompatible hydrogel tissue adhesives entirely made of naturally derived ingredients. We select two natural polymers, chitosan and gelatin, to construct the backbone and a bioderived compound, genipin, as the cross-linker. We show that, upon gelation, genipins cross-link chitosan and gelatin to form two interpenetrated networks and interlink them to tissue surfaces. Meanwhile, hydrogen bonds form in the matrix to strengthen the networks and at the interface to strengthen the adhesion between the hydrogel and tissue. Furthermore, we elaborately use high initial polymer contents to induce topological entanglements in the polymer networks to toughen the hydrogel. The resulting chitosan–gelatin hydrogel provides a tough matrix, and the robust covalent interlinks and hydrogen bonds provide a strong interface, achieving a tensile strength of ∼190 kPa, a fracture toughness of 205.7 J/m², a mode I adhesion energy of 197.6 J/m², and a mode II adhesion energy of 51.2 J/m². We demonstrate that the hydrogel tissue adhesive is injectable, degradable, and noncytotoxic and can be used for the controlled release of the anticancer drug cisplatin. All-natural ingredient-based tough and biocompatible hydrogels are promising as tissue adhesives for biomedical and related applications.

更新日期：2023-12-26

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