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Fluorescence probes for sensing and imaging within Golgi apparatus
Coordination Chemistry Reviews ( IF 20.3 ) Pub Date : 2023-12-25 , DOI: 10.1016/j.ccr.2023.215618
Hui Wang , Xiaoting Zhang , Tiancong Xiu , Hongtong Wang , Ping Li , Bo Tang

As a crucial constituent of the endomembrane system in eukaryotic cells, the Golgi apparatus serves as a major transport hub for intracellular macromolecular transport. Its dysfunction is closely related to various diseases including malignancy and neurodegenerative diseases. In order to comprehend the pathological role of Golgi apparatus and its associated signaling molecules in diseases, a variety of assays for the measurement of Golgi biomarkers have been developed. Among them, small molecule fluorescent probes play an irreplaceable role in real-time in situ imaging of biomarkers due to their unique advantages such as high sensitivity, high spatial and temporal resolution, excellent reproducibility and low toxicity. In recent times, there has been a significant focus on the utilization of Golgi-targeted fluorescence probes to identify Golgi-related biomarkers in various human diseases. This review aims to comprehensively outline the recent advancements in Golgi-targeted small-molecule fluorescent probes, with emphasis on their chemical structures, detection mechanisms and applications. In addition, we present existing challenges in Golgi imaging and suggestions for the development of novel Golgi-targeted small-molecule fluorescence probes to facilitate research on Golgi-related diseases and signaling pathways.



中文翻译:

用于高尔基体内传感和成像的荧光探针

高尔基体作为真核细胞内膜系统的重要组成部分,是细胞内大分子运输的主要运输枢纽。其功能障碍与恶性肿瘤、神经退行性疾病等多种疾病密切相关。为了理解高尔基体及其相关信号分子在疾病中的病理作用,已经开发了多种用于测量高尔基体生物标志物的测定法。其中,小分子荧光探针以其高灵敏度、高时空分辨率、优异的重现性和低毒性等独特优势,在生物标志物实时原位成像中发挥着不可替代的作用。近年来,利用高尔基体靶向荧光探针来识别各种人类疾病中与高尔基体相关的生物标志物受到了极大的关注。本综述旨在全面概述高尔基体靶向小分子荧光探针的最新进展,重点介绍其化学结构、检测机制和应用。此外,我们还提出了高尔基体成像中存在的挑战,并提出了开发新型高尔基体靶向小分子荧光探针的建议,以促进高尔基体相关疾病和信号通路的研究。

更新日期:2023-12-26
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