Abstract

Methylation and amination reactions of 4Н-[1,2,3]triazolo[4,5-c][1,2,5]oxadiazole salts (K⁺, Ag⁺, Et₃NH⁺, DBUH⁺) have been studied for the first time. It has been shown that the reaction of these salts with MeI results in two methylation products: K and Et₃N salts produce 4- and 5-isomers in equal amounts, while Ag and DBU salts form mainly 4-isomer. It has been found that the main amination product of K and DBU salts of 4Н-[1,2,3]triazolo[4,5-c][1,2,5]oxadiazole with O-(p-tolylsulfonyl)hydroxylamine is 4-azido-3-amino-1,2,5-oxadiazole. A mechanism of its formation via rearrangement of 5-amino-[1,2,3]triazolo[4,5-c][1,2,5]oxadiazole has been proposed.

中文翻译：

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4H-[1,2,3]三唑并[4,5-c][1,2,5]恶二唑盐的甲基化和胺化

摘要

研究了4 Н -[1,2,3]三唑并[4,5- c ][1,2,5]恶二唑盐（K ⁺、Ag ⁺、Et ₃ NH ⁺、DBUH ⁺ ）的甲基化和胺化反应首次。已表明这些盐与MeI的反应产生两种甲基化产物：K和Et ₃ N盐产生等量的4-和5-异构体，而Ag和DBU盐主要形成4-异构体。研究发现4Н-[1,2,3]三唑并[4,5-c][1,2,5]恶二唑与O-(对甲苯磺酰基)羟胺的K盐和DBU盐的主要胺化产物是4-叠氮基-3-氨基-1,2,5-恶二唑。提出了其通过 5-氨基-[1,2,3]三唑并[4,5- c ][1,2,5]恶二唑重排形成的机制。