: Imidazo[1,2-a]pyridine is a highly significant fused bicyclic heterocycle widely utilized in medicinal chemistry, and it holds a prominent position as a "drug prejudice" framework because of its extensive applications. Numerous approaches have been documented for the synthesis of imidazo[1,2-a]pyridines, with a particular focus on functionalizing these compounds. In this research, we have presented an effective multi-step synthesis method for producing imidazo[1,2-a]pyridines, achieving impressive yields ranging from 93% to 97%. The synthesized compounds were subjected to thorough characterization using various spectral analysis techniques, including FTIR, 1H NMR, 13C NMR, mass spectrometry, and elemental analysis. Overall, this synthetic strategy possesses desirable features for the synthesis of imidazo[1,2-a]pyridines and their derivatives, including high product purity, accessible starting materials, broad substrate scope, scalability, and transformability. These characteristics make it a promising approach for further development and potential application in the synthesis of valuable therapeutic compounds.

中文翻译：

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6-取代-Np-甲苯基-咪唑并[1,2-a]吡啶-8-甲酰胺的高效合成和表征：一个有前途的药物开发支架

：咪唑并[1,2-a]吡啶是一种非常重要的稠合双环杂环，在药物化学中得到广泛应用，由于其广泛的应用，它在“药物偏见”框架中占有重要地位。已经记录了许多合成咪唑并[1,2-a]吡啶的方法，特别关注这些化合物的功能化。在这项研究中，我们提出了一种有效的多步合成方法来生产咪唑并[1,2-a]吡啶，收率高达 93% 至 97%。使用各种光谱分析技术（包括 FTIR、1H NMR、13C NMR、质谱和元素分析）对合成的化合物进行彻底表征。总体而言，该合成策略具有合成咪唑并[1,2-a]吡啶及其衍生物的理想特征，包括产品纯度高、起始原料易得、底物范围广、可扩展性和可转化性。这些特性使其成为进一步开发和合成有价值的治疗化合物的潜在应用的有前途的方法。