当前位置: X-MOL 学术Tetrahedron › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The use of microwave radiations and propylphosphonic anhydride (T3P®) for rapid and highly yielding amide bond formation and peptide coupling
Tetrahedron ( IF 2.1 ) Pub Date : 2023-12-23 , DOI: 10.1016/j.tet.2023.133813
Elisa Rouge , Jean Michel Brunel

An improved, fast, and efficient procedure for amide bond formation and peptide coupling is reported leading to the expected corresponding derivatives in good to excellent isolated yields ranging from 26 to 90%. The outcome of the reaction was also investigated in relation to the influence of different parameters such as the nature of the solvent, the temperature as well as the amine/carboxylic acid couple involved or the hydrolysis conditions.



中文翻译:

使用微波辐射和丙基膦酸酐 (T3P®) 快速、高产地形成酰胺键和肽偶联

据报道,一种改进的、快速且有效的酰胺键形成和肽偶联程序可产生预期的相应衍生物,其分离产率范围为 26% 至 90%,从良好到优异。还研究了反应结果与不同参数的影响,例如溶剂的性质、温度以及涉及的胺/羧酸对或水解条件

更新日期:2023-12-28
down
wechat
bug