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Invitro- invivo evaluations of green synthesized zinc oxide (ZnO) nanoparticles using Ipomoea aquatica leaf extract as matric and fillers
Journal of the Mechanical Behavior of Biomedical Materials ( IF 3.3 ) Pub Date : 2023-12-23 , DOI: 10.1016/j.jmbbm.2023.106330
Fahaduddin 1 , Trishna Bal 1
Affiliation  

The current study details the green synthesis of zinc oxide nanoparticles utilizing the aqueous leaf extract of Ipomoea aquatica. A straightforward, economically viable, and consistent green synthesis technique was devised for producing these nanoparticles. The resulting Zinc oxide nanoparticles underwent comprehensive characterization through XRD, FESEM, EDS, FT-IR, TGA, and DSC analyses. Additionally, the study encompassed In- vitro and In- vivo assessments, including examinations of anti-microbial effects, hemocompatibility, anti-inflammatory responses, oral toxicity in mice, and fish toxicity using the Danio rerio model. The toxicological evaluations were done using the Danio rerio model (fish toxicity) and oral toxicity studies on mice. The particle size and zeta potential were verified using a DLS study, while EDS analyses validated the elemental composition of the nanoparticles. The crystalline nature of the nanoparticles was confirmed through distinctive peaks in the XRD pattern. The HR-TEM results confirmed the particle size range obtained by the Light scattering technique. Encouraging results were observed across the range of pharmacological activities conducted, demonstrating positive outcomes in terms of anti-microbial, hemocompatibility, anti-inflammatory attributes, In-vitro cytotoxicity, oral toxicity, and fish toxicity. This study not only showcased an eco-friendly and cost-efficient method for synthesizing Zinc oxide nanoparticles but also highlighted their potential implications.



中文翻译:


使用水薯叶提取物作为基质和填料对绿色合成氧化锌 (ZnO) 纳米颗粒进行体内-体内评价



目前的研究详细介绍了利用水薯叶水提取物绿色合成氧化锌纳米粒子。设计了一种简单、经济可行且一致的绿色合成技术来生产这些纳米颗粒。所得氧化锌纳米颗粒通过 XRD、 FESEM 、EDS、FT-IR、 TGA和 DSC 分析进行了全面表征。此外,该研究还包括体外和体内评估,包括使用斑马鱼模型检查抗菌作用、血液相容性、抗炎反应、小鼠口服毒性和鱼类毒性。使用斑马鱼模型(鱼毒性)和小鼠口服毒性研究进行毒理学评估。使用 DLS 研究验证了颗粒尺寸和 zeta 电位,同时 EDS 分析验证了纳米颗粒的元素组成。纳米粒子的结晶性质通过 XRD 图案中的独特峰得到证实。 HR-TEM 结果证实了通过光散射技术获得的粒径范围。在所进行的一系列药理活动中观察到了令人鼓舞的结果,证明了在抗菌、血液相容性、抗炎特性、体外细胞毒性、口服毒性和鱼类毒性方面的积极成果。这项研究不仅展示了一种环保且经济高效的合成氧化锌纳米颗粒的方法,而且还强调了它们的潜在影响。

更新日期:2023-12-27
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