An Intelligent DNA Nanoreactor for Easy-to-Read In Vivo Tumor Imaging and Precise Therapy,Angewandte Chemie International Edition

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An Intelligent DNA Nanoreactor for Easy-to-Read In Vivo Tumor Imaging and Precise Therapy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-12-23 , DOI: 10.1002/anie.202311309
Dongsheng Mao _{1,

2} , Ziliang Dong ₂ , Xueliang Liu ₂ , Wenxing Li ₁ , Hongyi Li ₂ , Chao Gu ₂ , Ganghui Chen ₂ , Xiaoli Zhu ₁ , Yu Yang ₂

Affiliation

An intelligent DNA nanoreactor (iDNR) following an “AND” Boolean logic algorithm was constructed. iDNR exhibits superior stability, improved binding affinity, and superior targeting/retention capability. It addresses previous limitations such as always “ON” or single-parameter responsive signal output, off-target effects, and high cost. Therefore, it enables the development of similar iDNRs for various biomedical applications.

中文翻译：

智能 DNA 纳米反应器，可实现易于读取的体内肿瘤成像和精准治疗

构建了遵循“AND”布尔逻辑算法的智能DNA纳米反应器（iDNR）。 iDNR 表现出卓越的稳定性、改进的结合亲和力和卓越的靶向/保留能力。它解决了以前的限制，例如始终“开启”或单参数响应信号输出、脱靶效应和高成本。因此，它可以为各种生物医学应用开发类似的 iDNR。

更新日期：2023-12-23

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