Synthesis and characterization of drug metabolites has emerged as an important area of research in consideration to the significant contribution of studies on metabolites in drug research. The present work comprises synthesis of 2-(4-((4-chlorophenyl)(hydroxy)methyl) phenoxy)-2-methylpropanoic acid, a metabolite of anti-hyperlipidemic drug fenofibrate. The desired compound was prepared by two different synthetic routes. The ketone group of fenofibric acid was reduced using sodium borohydride in one route whereas the hydrolysis of isopropyl ester of the reduced fenofibrate was achieved by the mild alkaline hydrolysis in the other path. Both the ways of synthesis furnished the desired compound in excellent yield and purity. The new synthetic congener was characterized by spectroscopic methods.

中文翻译：

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2-(4-((4-氯苯基)(羟基)甲基)苯氧基)-2-甲基丙酸的简便合成：抗高血脂药物非诺贝特的代谢物


考虑到代谢物研究在药物研究中的重要贡献，药物代谢物的合成和表征已成为一个重要的研究领域。目前的工作包括合成2-(4-((4-氯苯基)(羟基)甲基)苯氧基)-2-甲基丙酸，它是抗高血脂药物非诺贝特的代谢产物。通过两种不同的合成路线制备所需的化合物。在一条途径中，使用硼氢化钠还原非诺贝特酸的酮基团，而在另一条途径中，通过温和的碱性水解实现还原的非诺贝特的异丙酯的水解。两种合成方法都以优异的产率和纯度提供了所需的化合物。新的合成同系物通过光谱方法进行了表征。