1,3-propanediol (1,3-PDO) is a vital value-added bi-functional compound that has numerous uses in the industrial sector including the polymer, pharmaceutical, food, and cosmetics industries. 1,3-PDO biosynthesis from renewable resources through green methods has received considerable attention. However, technical difficulties such as low product titer, by-product accumulation, and incomplete substrate consumption impede its sustainable production at the industrial scale. Hence, understanding the overall 1,3-PDO process development with integrated knowledge of techno-economics would help to build more production facilities across the world. In this view, the biotechnological production of 1,3-PDO is systematically reviewed briefing the synthesis routes, microbial strains, metabolic pathways, and fermentation modes along with several purification strategies. The present review also summarizes key hurdles in 1,3-PDO production and discusses the attainable solutions to achieve higher product titer. Finally, the economic viability of 1,3-PDO biosynthesis is described based on the existing research.

中文翻译：

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微生物 1, 3-丙二醇生产综述：重建其商业利益的新兴战略、关键障碍和可实现的解决方案


1,3-丙二醇 (1,3-PDO) 是一种重要的增值双功能化合物，在工业领域有多种用途，包括聚合物、制药、食品和化妆品行业。通过绿色方法从可再生资源生物合成1,3-PDO受到了广泛关注。然而，产品效价低、副产物积累、底物消耗不完全等技术难题阻碍了其工业规模的可持续生产。因此，通过综合技术经济知识了解 1,3-PDO 工艺的整体开发将有助于在世界各地建立更多的生产设施。本文对 1,3-PDO 的生物技术生产进行了系统的综述，简要介绍了 1,3-PDO 的合成路线、微生物菌株、代谢途径和发酵模式以及几种纯化策略。本综述还总结了 1,3-PDO 生产的关键障碍，并讨论了实现更高产品滴度的可行解决方案。最后，根据现有研究描述了1,3-PDO生物合成的经济可行性。