Dimethylglycine Alleviates Metabolic Dysfunction-Associated Fatty Liver Disease by Improving the Circulating Estrogen Level via Gut Staphylococcus,Journal of Agricultural and Food Chemistry

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Dimethylglycine Alleviates Metabolic Dysfunction-Associated Fatty Liver Disease by Improving the Circulating Estrogen Level via Gut Staphylococcus
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-12-22 , DOI: 10.1021/acs.jafc.3c07075
Hong Yao ₁ , Yan Hu ₁ , Haibing Tong ₁ , Shourong Shi ₁

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Our previous study screened out dietary 0.1% dimethylglycine (DMG), which had beneficial effects on egg production and fat deposition in laying hens during the late laying period. In this paper, it was further found that dietary DMG alleviated fatty liver disease and enhanced lipid deposited into the yolk while promoting hepatic lipid transport. There are intestinal estrogen-metabolizing bacteria (EBM) having β-glucuronase (GUS) activity that regulates the content of circulating estrogen (E2) in mammals. There were 39 related bacteria found in laying hens, and DMG increased E2 in blood, Staphylococcus abundance among EBM and GUS activity in cecum chyme. Interfered in situ, Staphylococcus with GUS activity was proved the target bacteria for DMG. Furthermore, E2 could modify hepatic lipid deposition through promoting lipid transport by the steatosis LMH model. These perspectives confirm that DMG, mediated by Staphylococcus, alleviates the restriction of hepatic lipid transport due to reduced levels of E2 in laying hens.

中文翻译：

二甲基甘氨酸通过肠道葡萄球菌改善循环雌激素水平，减轻代谢功能障碍相关的脂肪肝

我们前期的研究筛选出日粮中添加0.1%二甲基甘氨酸（DMG），对蛋鸡产蛋后期的产蛋量和脂肪沉积有有益的作用。在本文中，进一步发现膳食DMG可减轻脂肪肝疾病并增强脂质沉积到蛋黄中，同时促进肝脏脂质转运。肠道雌激素代谢细菌（EBM）具有β-葡萄糖醛酸酶（GUS）活性，可调节哺乳动物体内循环雌激素（E2）的含量。在蛋鸡体内发现了39种相关细菌，DMG增加了血液中的E2、EBM中的葡萄球菌丰度和盲肠食糜中的GUS活性。原位干扰，具有GUS活性的葡萄球菌被证明是DMG的目标细菌。此外，E2 可以通过脂肪变性 LMH 模型促进脂质转运，从而改变肝脏脂质沉积。这些观点证实，由葡萄球菌介导的 DMG 可以缓解蛋鸡中因 E2 水平降低而导致的肝脏脂质运输限制。

更新日期：2023-12-22

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