A highly efficient synthesis of [1,2,3]triazolo[5,1-a]isoquinoline derivatives was developed that proceeds through copper-catalyzed tandem Sonogashira coupling/regioselective 6-endo cyclization. This NH-triazole-directed annulation approach showed good functional-group tolerance and gave the corresponding N-fused heterocycles in good to excellent yields.

中文翻译：

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通过铜催化串联 Sonogashira 偶联/环化反应轻松合成 [1,2,3] 三唑并 [5,1-a] 异喹啉

开发了 [1,2,3] 三唑并 [5,1-a] 异喹啉衍生物的高效合成，其通过铜催化串联 Sonogashira 偶联/区域选择性 6-内环化进行。这种 NH-三唑导向的环化方法显示出良好的官能团耐受性，并以良好到极好的产率得到相应的 N-稠合杂环。