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Synthesis And Anticancer Activity Of New Hybrid 3-Methylidene-2,3-Dihydro-1,8-Naphthyridinones
ChemMedChem ( IF 3.6 ) Pub Date : 2023-12-21 , DOI: 10.1002/cmdc.202300519 Agata Jaskulska 1 , Jacek Szymański 2 , Piotr F J Lipiński 3 , Jakub Modranka 1 , Anna E Janecka 4 , Tomasz Janecki 1 , Katarzyna Gach-Janczak 4
ChemMedChem ( IF 3.6 ) Pub Date : 2023-12-21 , DOI: 10.1002/cmdc.202300519 Agata Jaskulska 1 , Jacek Szymański 2 , Piotr F J Lipiński 3 , Jakub Modranka 1 , Anna E Janecka 4 , Tomasz Janecki 1 , Katarzyna Gach-Janczak 4
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New hybrid 3-methylidene-2,3-dihydro-1,8-naphthyridinones are highly cytotoxic against promyelocytic leukemia HL-60 cells. Anticancer activity of the most selective compound in this series is associated with inhibition of cell proliferation and induction of apoptosis, which could be attributed to its ability to induce DNA damage. New hybrid compounds can serve as lead structures for finding new anticancer agents.
中文翻译：
新型杂化3-亚甲基-2,3-二氢-1,8-萘啶酮的合成及其抗癌活性
新型杂化 3-亚甲基-2,3-二氢-1,8-萘啶酮对早幼粒细胞白血病 HL-60 细胞具有高度细胞毒性。该系列中最具选择性的化合物的抗癌活性与抑制细胞增殖和诱导细胞凋亡有关，这可能归因于其诱导 DNA 损伤的能力。新的杂化化合物可以作为寻找新抗癌药物的先导结构。
更新日期：2023-12-21
中文翻译：
新型杂化3-亚甲基-2,3-二氢-1,8-萘啶酮的合成及其抗癌活性
新型杂化 3-亚甲基-2,3-二氢-1,8-萘啶酮对早幼粒细胞白血病 HL-60 细胞具有高度细胞毒性。该系列中最具选择性的化合物的抗癌活性与抑制细胞增殖和诱导细胞凋亡有关，这可能归因于其诱导 DNA 损伤的能力。新的杂化化合物可以作为寻找新抗癌药物的先导结构。
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