A convenient methodology for the preparation of 6-functionalized azabicyclo[4.1.0]heptane-derived building blocks is developed. The common synthetic precursor – tert-butyl 6-(hydroxymethyl)-3-azabicyclo[4.1.0]heptane-3-carboxylate was obtained in 4 steps starting from readily available 4-hydroxymethyl pyridine. Other 6-functionalized and 3,6-difunctionalized azabicyclo[4.1.0]heptane-derived building blocks (including novel bicyclic γ-amino acid) were prepared in short synthetic pathways through 1–3 steps.

中文翻译：

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6-官能化氮杂双环[4.1.0]庚烷衍生物的便捷合成

开发了一种制备 6-官能化氮杂双环[4.1.0]庚烷衍生结构单元的便捷方法。常见的合成前体 - 6-（羟甲基）-3-氮杂双环[4.1.0]庚烷-3-甲酸叔丁酯是从容易获得的 4-羟甲基吡啶开始，分 4 个步骤获得的。其他 6-官能化和 3,6-双官能化氮杂双环[4.1.0]庚烷衍生结构单元（包括新型双环 γ-氨基酸）通过 1-3 个步骤以短合成途径制备。