Cell-Penetrating Peptide-Bismuth Bicycles**,Angewandte Chemie International Edition

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Cell-Penetrating Peptide-Bismuth Bicycles**
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-12-21 , DOI: 10.1002/anie.202318615
Saan Voss _{1,

2} , Liam D Adair _{3,

4} , Katharina Achazi ₅ , Heeyoung Kim _{6,

7} , Silke Bergemann ₂ , Ralf Bartenschlager _{6,

7} , Elizabeth J New _{3,

4} , Jörg Rademann ₂ , Christoph Nitsche ₁

Affiliation

Peptide-bismuth bicycles can effectively penetrate human cell membranes. They are easy to synthesize, require only three positive charges for cell entry, and their uptake can be monitored by mass spectrometry due to the unique ability to trace bismuth. This discovery offers an alternative to fluorophore labeling and opens new possibilities for designing therapeutic agents with improved cellular uptake and traceability.

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