To balance the permeability-selectivity trade-off effect of the polyamide nanofiltration membrane, interfacial polymerization regulation strategy is widely used to optimize the physicochemical structure of the polyamide film. In the present work, the compound additives of phytic acid and ferric chloride were added into the aqueous phase to regulate the interfacial polymerization process. On the one hand, a lot of piperazine monomers will be adsorbed around the phytic acid molecules due to the electrostatic interaction between phosphoric acid groups and amino groups. Meanwhile, the phytic acid molecules and ferric ions can form a complex in the piperazine solution, which results in a low diffusion rate of the other piperazine monomers without adsorbed on the phytic acid and ferric chloride complex due to steric hindrance. The synergistic effect of electrostatic interaction and steric hindrance leads to the optimized nanofiltration membrane with a thinner and looser polyamide structure. The best-performing nanofiltration membrane exhibits an approximately four-fold water permeance (28.4 L m⁻² h⁻¹ bar⁻¹) compared with the controlled M0 nanofiltration membrane (6.5 L m⁻² h⁻¹ bar⁻¹) without obviously sacrificing the Na₂SO₄ rejection (96.9 %). This simple interfacial polymerization regulation strategy provides a novel insight for the preparation of high-performance NF membrane.