Metabolism of Two Mogroside Isomers, Mogroside III and Mogroside IIIE, in Normal and Drug-Metabolizing Enzyme-Induced Rats,Journal of Agricultural and Food Chemistry

当前位置： X-MOL 学术 › J. Agric. Food Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Metabolism of Two Mogroside Isomers, Mogroside III and Mogroside IIIE, in Normal and Drug-Metabolizing Enzyme-Induced Rats
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-12-15 , DOI: 10.1021/acs.jafc.3c07938
Xuerong Yang ₁ , Feng Xu ₂ , Fenglai Lu ₁ , Wen He ₃ , Jingru Song ₁ , Xiaojie Yan ₁ , Jianxing Li ₃ , Guangxue Liu ₂ , Shaoqing Cai ₂ , Dianpeng Li _{1,

4}

Affiliation

Mogrosides III (1) and IIIE (2) are two important bioactive cucurbitane-type triterpenoid triglycosides in the edible fruits of Siraitia grosvenorii (Swingle), which are isomers and have only a minor difference in their structures. To clarify the effects of structural difference and drug-metabolizing-enzyme induction on their metabolism in vivo, their metabolites in normal rats and drug-metabolizing-enzyme-induced rats were tentatively identified and semiquantified by using the HPLC-DAD-ESI-IT-TOF-MSⁿ technique. Totally, 76, 78, 96, and 121 metabolites of mogrosides were identified in the NIII (normal rats orally administered with mogroside III), NIIIE (normal rats orally administered with mogroside IIIE), EIII (drug-metabolizing-enzyme-induced rats orally administered with mogroside III), and EIIIE (drug-metabolizing-enzyme-induced rats orally administered with mogroside IIIE) groups, respectively. The metabolite differences among these groups indicated that their minor structural differences are responsible for the significant differences in their metabolites, and the induction of drug-metabolizing enzymes significantly increased the number of their metabolites. These findings would improve our understanding of the in vivo processes of mogrosides III and IIIE as well as their interactions with other food bioactive components or drugs.

中文翻译：

两种罗汉果苷异构体罗汉果苷 III 和罗汉果苷 IIIE 在正常和药物代谢酶诱导大鼠中的代谢

罗汉果苷III( 1 )和IIIE( 2 )是罗汉果食用果实中两种重要的具有生物活性的葫芦烷型三萜三糖苷，它们是同分异构体，结构上仅有微小差异。为了阐明结构差异和药物代谢酶诱导对其体内代谢的影响，利用HPLC-DAD-ESI-IT-对正常大鼠和药物代谢酶诱导大鼠的代谢物进行了初步鉴定和半定量。 TOF-MS ⁿ技术。在NIII（正常大鼠口服罗汉果苷III）、NIIIE（正常大鼠口服罗汉果苷IIIE）、EIII（药物代谢酶诱导大鼠口服罗汉果苷III）中总共鉴定出76、78、96和121种罗汉果苷代谢物。分别给予罗汉果苷III)组和EIIIE组(口服罗汉果苷IIIE药物代谢酶诱导大鼠)组。这些组之间的代谢物差异表明，它们的微小结构差异导致了它们代谢物的显着差异，并且药物代谢酶的诱导显着增加了它们代谢物的数量。这些发现将提高我们对罗汉果苷 III 和 IIIE 体内过程以及它们与其他食品生物活性成分或药物相互作用的理解。

更新日期：2023-12-15

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南